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| Clinical value of the levels of maternal blood soluble myeloid cell trigger receptor-1 and macrophage inflammatory protein-3αfor predicting premature rupture of membranes complicated with intrauterine infection |
| Hainan Modern Women and Children's Hospital, Haikou, Hainan Province, 571100 |
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Abstract To explore the clinical value of maternal blood soluble myeloid cell trigger receptor-1 (sTREM-1) and macrophage inflammatory protein-3α(MIP-3α) levels for predicting premature rupture of membranes complicated with intrauterine infection. Methods: The clinical data of 219 pregnant women with premature rupture of membranes from May 2019 to May 2022 were collected prospectively. The levels of maternal blood sTREM-1 and MIP-3α of the women at admission were detected by enzyme-linked immunosorbent assay. These women were divided into group A (58 women with intrauterine infection) and group B (161 without intrauterine infection). The diagnostic value of maternal blood sTREM-1 and MIP-3α for diagnosing the premature rupture of membranes complicated with intrauterine infection was evaluated by receiver operating characteristic curve (ROC). The risk factors of the premature rupture of membranes complicated with intrauterine infection were explored by multivariate logistic regression analysis. Results: The levels of prenatal sTREM-1 and MIP-3α in blood (72.16±8.43 pg/ml and 49.62±5.39 pg/ml) of the women in group A were significantly higher than those (31.05±4.18 pg/ml and 25.16±3.24 pg/ml) of the women in group B (P＜0.05). The area under curve (AUC) of the blood sTREM-1 and MIP-3α levels of the women for predicting their premature rupture of membranes combined with intrauterine infection were 0.832 and 0.769, the cutoff values of which were 51.61pg/ml and 37.39pg/ml, the specificity of which were 67.5% and 52.3%, and the sensitivity of which were 93.1% and 93.1%. The AUC, the specificity, and the sensitivity of the combined of blood sTREM-1 and MIP-3α levels of the women for predicting their premature rupture of membranes combined with intrauterine infection were 0.911, 85.4%, and 86.2%, respectively. Preterm premature rupture of membranes, sTREM-1≥51.61pg/ml, MIP-3α≥37.39pg/ml of the women with premature rupture of membranes were the risk factors of their intrauterine infection (P＜0.05). Conclusion: The levels of serum sTREM-1 and MIP-3α of the pregnant women with premature rupture of membranes complicated with intrauterine infection increase abnormally, and both of which can be used as biological indicators for predicting intrauterine infection of the pregnant women with premature rupture of membranes, and the combined detections of the levels of serum sTREM-1 and MIP-3α of the women can increase the predicting specificity.
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