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| Correlation between the blood glucose and lipid levels of pregnant women with hypothyroidism during pregnancy and their severity of hypothyroidism and pregnancy outcomes |
| The Second Affiliated Hospital of Chengdu Medical College (416 Hospital of Nuclear Industry), Chengdu, Sichuan Province, 610057 |
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Abstract To explore the correlation between the blood glucose and lipid levels of pregnant women with hypothyroidism during pregnancy and their severity of hypothyroidism and pregnancy outcomes. Methods：The clinical data of 180 pregnant women with hypothyroidism during pregnancy between August 2018 and April 2021 were collected. According to the severity of hypothyroidism, these women were divided into group A1 (75 women with hypothyroidism), group A2 (59 women with subclinical hypothyroidism), and group A3 (46 women with hypothyroxinemia). According to the pregnancy outcomes, these women were divided into group B1 (117 women with normal pregnancy outcomes) and group B2 (63 women with adverse pregnancy outcomes). The levels of glucose metabolism indexes, such as fasting blood glucose (FBG) and glycosylated hemoglobin (HbAlc), and lipid metabolism indexes, such as triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), and low density lipoprotein (LDL), of the women were compared among the three groups, and the value of which for predicting for the severity of hypothyroidism and pregnancy outcomes was analyzed. Results: The FBG level of the women in group A1 was significantly higher than that of the women in group A2, and of the women in group A3. The levels of HbAlc, TG, and LDL of the women in group A1, group A2, and group A3 had decreased gradually (all P＜0.05), there were no significant differences in the levels of TC and HDL of the women among the three groups (P>0.05). The levels of FBG, TG, LDL, and HbAlc of the women in group B1 were significantly lower than those of the women in group B2 (P＜0.05), there were no significant differences in the TC and HDL levels of the women between the two groups (P>0.05). The levels of FBG, HbAlc, TG, and LDL of the women were positively correlated with their severity of hypothyroidism (P＜0.05). The area under the curve (AUC) of the combined of glycemic and lipid metabolism indexes levels of the women for evaluating their severity of hypothyroidism and for predicting their pregnancy outcomes were 0.927 and 0.887, which were significantly higher than those of each index of glycemic and lipid metabolism (all P＜0.05). Conclusion: The glucose-lipid metabolism of the pregnant women with gestational hypothyroidism is abnormal. The combined detections of glucose-lipid metabolism indexes have evaluation value for the severity of hypothyroidism and pregnancy outcomes of the pregnant women with gestational hypothyroidism.
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