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| Effect of low molecular weight heparin combined with cyclosporine A for treating women with unexplained recurrent spontaneous abortion and its influence on the immune balance and hemorheology |
| The Third Hospital of Tangshan, Tangshan, Hebei Province,063000 |
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Abstract To observe the effect of low molecular weight heparin combined with cyclosporine A for treating pregnant women with unexplained recurrent spontaneous abortion (URSA), and to study its influence on the immune balance and hemorheology of these women. Methods: 83 pregnant women with URSA diagnosed and treated in the hospital were selected and divided into the research group (n=42) and control group (n=41) according to different treatment schemes from June 2017 to June 2021. On the basis of routine treatment of fetal protection, the women in the control group were given cyclosporine A, and the women in the research group were given low molecular weight heparin combined with cyclosporine A, and both of which were treated until 12 gestational weeks. The levels of T lymphocyte subsets, helper T cell (Th) 1 and Th2 related factors, the hemorheology indexes, the curative effect, the adverse reaction, and the success rate of fetal protection of the women were compared between the two groups. Results: The levels of serum CD8+, interleukin (IL) -10, and IL-4 of the women in both groups after treatment had increased significantly, while the levels of CD4+, CD4+/CD8+, interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α) of the women in both groups after treatment had decreased significantly, and the change ranges of which of the women in the research group were significantly more than those of the women in control group (P＜0.05). After treatment, the values of plasma viscosity, whole blood reductive viscosity high cut, and whole blood reductive viscosity low cut, and the fibrinogen level of the women in the research group were significantly lower than those of the women in the control group, the total effective rate (90.5%) of the women in the research group was higher than that of the women in the control group (73.2%), and the success rate of fetal protection (95.2%) of the women in the research group was significantly higher than that (78.1%) of the women in the control group (all P＜0.05). There was no significant difference in the adverse reactions (19.1% vs. 9.8%) of the women between the two groups (P＞0.05). Conclusion: Low molecular weight heparin combined with cyclosporine A for treating the pregnant women with URSA can promote their immune balance and hemorheology, which can significantly improve the curative effect and the success rate of fetal protection, with good safe and reliable.
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