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Abstract To explore the predictive value of prenatal ultrasound combined with coagulation markers of women for their postpartum lower extremity deep venous thrombosis. Methods: A retrospective analysis was performed on the clinical data of 1126 pregnant women with single fetus who had been given regular antenatal examination and delivered in hospital from January 2019 to March 2022. All these women had received lower limb ultrasound examination and coagulation markers detection before delivery. Among them, 43 women with postpartum lower limb deep vein thrombosis were included in observation group, and another 50 women were randomly selected in control group from the rest women. The results of prenatal lower extremity examined by ultrasonography and the coagulation markers level of the women were compared between the two groups. Results: The ultrasound positive rate (48.8%) of the women in the observation group was significantly higher than that (12.0%) of the women in the control group, and the levels of fibrinogen (FIB), D-dimer (D-D), and thrombin regulating protein (TM), and the plasminase-anti-plasminase complex (PAP) value of the women in the observation group were significantly higher than those of the women in the control group (all P＜0.05). There were no significant differences in the values of prothrombin time (PT), activated partial prothrombin time (APTT), and thrombin time (TT) of the women between the two groups (P＞0.05). The receiver operating characteristic (ROC) curve analysis showed that the AUC of prenatal ultrasound results, the D-D level, the TM level, and the PAP value of the women for predicting their postpartum DVT were 0.733, 0.712, 0.811, and 0.869, respectively. The optimal truncation values of the D-D level, the TM level, and the PAP value of the women for predicting their postpartum DVT were 4.59 mg/L, 34.12 ng/L, and 1.95μg/L, respectively, the sensitivity of which were 73.2%, 71.9%, 74.3%, and 84.7%, respectively, and the specificity of which were 80.8%, 82.3%, 86.2%, and 79.3%, respectively. The AUC, the sensitivity, and the specificity of ultrasound results combined with the coagulation markers values of the women for predicting their postpartum DVT were 0.909, 98.6%, and 95.4%, respectively. Conclusion: The examination of lower extremity by prenatal ultrasonography combined with the coagulation markers detection of the women has high sensitivity and specificity for predicting the postpartum lower extremity deep vein thrombosis of the women, which has a certain warning value.
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