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| Effects of carboprost tromethamine combined with balloon compression for treating post-cesarean hemorrhage of women with placenta previa on their coagulation function and stress state |
| 1. Sami Medical Center (The Fourth People's Hospital of Shenzhen), Shenzhen, Guangdong Province, 518000; 2.The Third Affiliated Hospital of Qiqihar Medical College, Qiqihar, Heilongjiang Province; 3. The First Hospital of Qiqihar, Heilongjiang Province |
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Abstract To explore the effects of carboprost tromethamine combined with balloon compression for treating post-cesarean hemorrhage of women with placenta previa on their coagulation function and stress state. Methods: A total of 84 women with postpartum hemorrhage after cesarean section due to placenta previa were selected and divided into two groups (42 cases in each group) by random number table from May 2017 to May 2022. The women in the control group were given one-time intrauterine balloon compression therapy, while the women in the observation group were given prostaglandin tromethamine combined with balloon compression therapy. The blood loss, coagulation function, stress state, and complications situation of the women were compared between the two groups. Results: The blood loss of the women in the control group during delivery (381.52±45.15 ml), postpartum 2h (296.47±38.15 ml), and postpartum 24h (352.14±41.16 ml) were significantly more than those (235.74±34.61 ml and 198.74±27.16 ml, and 273.06±36.15 ml) of the women in the observation group (P＜0.05). The serum fibrinogen level, the prothrombin time, and activated partial thrombin time of the women in the two groups after treatment had decreased significantly, and which (3.17±0.43 g/L, 10.16±1.13s, and 37.04±3.08s) of the women in the observation group were significantly lower than those (4.25±0.62g/L, 13.74±1.21s, and 45.17±3.41s) of the women in the control group. The levels of serum norepinephrine, epinephrine, and cortisol of the women in the two groups after treatment had increased significantly, but which (297.45±28.66 pg/ml, 52.65±6.47 pg/ml, and 274.26±35.21 ng/ml) of the women in the observation group were significantly lower than those (354.06±34.12) pg/ml, 69.58±7.21 pg/ml, and 327.28±43.05 ng/ml) of the women in the control group (all P＜0.05). The complication rate (9.5%) of the women in the observation group had no significantly different from that (19.0%) of the women in the control group (P=0.212). Conclusion: Carboprost tromethamine combined with balloon compression for treating post-cesarean hemorrhage of women with placenta previa has a significant clinical effect, which can improve the coagulation function, effectively control the stress state of the women, with higher safety.
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