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Abstract To investigate the risk factors of spontaneous preterm birth of women with twin pregnancies. Methods：The clinical data of the women with twin pregnancies who had delivered in the fourth hospital Shijiazhuang from June 2015 to June 2020 were analyzed retrospectively. The women with preterm premature rupture of membranes, and iatrogenic preterm birth, and incomplete clinical data were excluded from this research. 298 women delivered during 28-36+6 gestational weeks were included in group A, and 1367 women delivered during ≥37 gestational weeks were included in group B. The clinical data of the women were compared between the two groups. The risk factors of spontaneous preterm delivery of the women with twin pregnancies were analyzed. Results: Logistic regression analysis showed that, the age <25 years old at delivery (OR=1.691, 95%CI 1.108-2.580), the history of preterm delivery (OR=4.828, 95%CI 1.28418.161), the history of early pregnancy (OR=1.592, 95%CI 1.284-18.161), the history of preventing miscarriage during the first trimester of pregnancy (OR=1.592, 95%CI 1.184-2.142), the monochorionic (OR=2.82, 95%CI 1.972-4.034), the vaginitis (OR=2.047, 95%CI 1.049-3.995), the anemia (OR=2.633, 95%CI 1.900-3.648), the cervical insufficiency (OR=5.961, 95%CI 2.986-11.901), the uterine malformation (OR=7.843, 95%CI 1.323-46.487) of the women with twin pregnancies were the risk factors of their spontaneous preterm birth. The twin pregnancies women with pre-pregnancy weight 55-65kg had less weight gain during pregnancy than those women with pre-pregnancy weight ≤55kg (OR=1.711, 95%CI 1.147-2.466), and the women with pre-pregnancy weight > 65kg had less weight gain during pregnancy than those women with pre-pregnancy weight ≤55kg (OR=2.31, 95%CI 1.356-3.783), and which were the risk factors of their spontaneous preterm birth. Compared with those twin pregnancies women with ≤70kg at delivery, the women with weight 70-85kg (OR=0.373, 95%CI 0.2540.547), and the women with weight >85kg (OR=0.229, 95%CI 0.134-0.392) of the women were the risk factors of their spontaneous preterm birth. Conclusion: The age <25 years old, the history of preterm birth, the history of preventing miscarriage during the first trimester of pregnancy, the monochorionic, the vaginitis, the anemia, the cervical insufficiency, the uterine malformation, the less weight gain during pregnancy, and other high-risk factors of the women with twin pregnancies should be paid more attention to, and based on which to formulate the individualized intervention measures, so as to improve the maternal and infant prognosis.
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