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Abstract To analyze the predictive value of serum free-β- human chorionic gonadotropin (β-HCG) level combined with the levels of blood clotting tetrachoric pregnant women with cytomegalovirus (HCMV) infection for their adverse pregnancy outcomes. Methods: 58 pregnant women with HCMV infection were selected in study group, and 58 healthy pregnant women were selected in control group from October 2018 to April 2021. The general clinical data, the levels of bloodβ-HCG and coagulation function indexes were compared between the women in the two groups and between the women with and without adverse pregnancy outcomes in the study group. The values of free-β-HCG, activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), and fibrinogen (FIB) of the women with HMCV infection for predicting their adverse pregnancy outcomes was analyzed. Results: The levels of blood HCG, APTT, PT, and TT of the women in the study group were significantly lower than those of the women in the control group, and the FIB level of the women in the study group was significantly higher. In the study group, the levels of blood HCG, APTT, PT, and TT of the women with adverse pregnancy outcomes were significantly lower than those of the women with normal pregnancy outcomes, and the FIB level of the women with adverse pregnancy outcomes was significantly higher (all P<0.05). The levels of blood HCG, APTT, PT, TT, and FIB of the pregnant women with HCMV infection had certain predictive value for their adverse pregnancy outcomes, and the area under the curve of the combined detections of the levels of blood HCG, APTT, PT, TT, and FIB for predicting the adverse pregnancy outcomes was the highest (0.903), with a sensitivity of 85.7% and a specificity of 79.6%. Conclusion: The expression level of free β-HCG of the pregnant women with HCMV infection decreases, and the women have the situation of hypercoagulable blood, especially those women with adverse pregnancy outcomes. The combined detections of the levels of blood HCG, APTT, PT, TT, and FIB of the women for predicting their adverse pregnancy outcomes has higher value, which has certain guiding significance for early intervention.
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