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| Analysis of clinical characteristics and treatment outcomes of pregnant women with thrombocytopenia because of different aetiologies |
| The First Affiliated Hospital of Xinxiang Medical College, Henan Province, 453100 |
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Abstract To analyze the clinical characteristics and pregnancy outcomes of pregnant women with thrombocytopenia because of different aetiologies. Methods: The clinical data of 118 pregnant women with thrombocytopenia from May 2018 to December 2020 were selected, and these women were divided in group A (women with gestational thrombocytopenia (GT)), group B (women with idiopathic thrombocytopenic purpura (ITP)), group C (women with hypertensive disorder complicating pregnancy (HDCP)), and group D (women with others aetiologies) according to the different aetiologies. And according to the severity of thrombocytopenia of the women based on the results of the platelet count (PLT) test, these women were also divided into group E (women with PLT <100×109/L), group F (women with PLT 20-50×109/L), and group G (women with PLT <20×109/L). The distribution of the women with thrombocytopenia because of different etiologies, and the severity of thrombocytopenia of the women were observed. The pregnancy outcomes after treatment were compared among the women with thrombocytopenia because of different etiologies, and among the women with different severity of thrombocytopenia. Results: There were 66 (55.9%) women in group A, 26 (22.0%) women in group B, 17 (14.4%) women in group C, and 9 (7.6%) women in group D. There were significant differences in the proportions of different severity of thrombocytopenia of the women among group A, group B, group C, and group D (P<0.05). In group A, the proportion of mild thrombocytopenia of the women was significantly higher than that of moderate to severe thrombocytopenia of the women. In group B, the proportion of moderate to severe thrombocytopenia of the women was significantly higher than that of mild thrombocytopenia of the women (all P<0.05). There were no significant differences in the proportions of the different severity of thrombocytopenia of the women in group C (P＞0.05), and the proportion of severe thrombocytopenia of the women in group D was significantly higher than that of mild thrombocytopenia of the women (P<0.05). The rates of cesarean section and blood transfusion of the women in group A were significantly lower than those of the women in group B, group C, or group D (P<0.05). The rates of preterm birth and asphyxia of newborns had no significant differences between group A and group B, and which in group A and group B were significantly lower than those in group C and group D (all P<0.05). The postpartum hemorrhage rate (12.1%) of the women in group E was significantly higher than that (0) of the women in group G. The preterm birth rate (46.4%) and asphyxia rate (17.9%) of the women in group G were significantly higher than those (10.5% and 1.8%) of the women in group E (all P<0.05). Conclusion: The causes of thrombocytopenia of the pregnant women are various, and the severity, the treatment, and the prognosis also vary among the women with different causes of thrombocytopenia. GT is the common cause of thrombocytopenia, and the pregnancy outcomes of the women with thrombocytopenia by GT are good. The severity of thrombocytopenia of the women by other causes is quite serious, and the pregnancy outcomes are relatively poor. So, the timely diagnosis, and reasonable and standardized treatment of thrombocytopenia of the pregnant women can improve their prognosis.
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