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Abstract To explore the effect of mifepristone for treating patients after curettage of scar pregnancy. Methods: From January 2018 to October 2021，166 patients with HCG level >500U/L in 1 week after uterine curettage of scar pregnancy were included in this study. Among them, there were 57 cases with mifepristone treatment after direct curettage in group A, 51 cases without mifepristone treatment after direct curettage in group B, 25 cases with mifepristone treatment after interventional therapy and curettage in group C, and 33 cases without mifepristone treatment after interventional therapy and curettage in group D. The clinical effects of the patients were compared between group A and group B, and between group C and group D. Results: There were significant differences in the blood human chorionic gonadotropin (hCG) levels in the 4th week after direct uterine curettage 28.00(13.25, 57.25) U/L vs. 57.00(28.00, 122.60) U/L and in the 6th week after direct uterine curettage 4.22(0.10, 8.66) U/L vs. 13.00(5.50, 31.40) U/L of the patients between group A and group B (P＜0.05). There were significant differences in the time of blood hCG returning to normal (39.0±8.9 d vs. 48.8±10.6 d), the time of menstruation recovery (39.4±9.4 vs.49.4±14.6 d), the disappearance time of incision mass (48.7±13.8 d vs. 55.4±14.7 d ), and the review times during follow-up (5(5,6) times vs. 7(7,8) times) of the patients between group A and group B (P＜0.05). There were no significant differences in the blood hCG levels in the 4th week after direct uterine curettage and in the 6th week after direct uterine curettage of the patients between group C and group D (P>0.05). There were no significant differences in the time of blood hCG returning to normal, the time of menstruation recovery, the disappearance time of incision mass, and the review times during follow-up of the patients between group C and group D (P>0.05). Conclusion: Mifepristone used to treating the patients with unsatisfied decrease of serum hCG level or poor absorption of scar mass after direct uterine curettage can speed up their serum hCG level returning to normal, can promote the recovery of their menstruation and the disappearance of their incision mass, and can reduce the number of their postoperative follow-up.
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