To discuss the effects of continuous epidural anesthesia during induction of labor of primipara with the second trimester of pregnancy on their pregnancy again and their next pregnancy outcomes by a two-way cohort study. Methods: The study was launched in December 2017. The medical history data of the parturients who were had accepted the induction of labor during the second trimester of pregnancy(15-24 gestational weeks) from January 2014 to December 2015 were collected retrospectively. 291 parturients with continuous epidural anesthesia during induction of labor were included in group A, and 312 parturients without any anesthesia treatment during induction of labor were included in group B. The parturients with data ≥2 years of followed up retrospectively were included in group C. In December 2017, and the situation of re-pregnancy of the parturients after induction of labor was collected by looking up their medical record and telephone consulting during follow-up. Prospective cohort study was conducted in the parturients with re-pregnancy successful in group D. Then the re-pregnancy within 2-3 years and their repregnancy outcomes of the parturient with different anesthesia methods in group C and group D were analyzed prospectively. Results: The visual analogue scale(VAS) of the parturients in group C and group D had increased gradually with the conducting of induction of labor, and which of the parturients in group A was significantly lower than that of the parturients in group B. The postoperative blood loss(100.3±8.5 mL) of the parturients in group A was significantly lower than that(123.1±8.4 ml) of the parturients in group B(all P<0.05). The incidences of adverse reactions, such as movement disorders, low back pain, and headache of all the parturients were very low, and which of the parturients had no significant different between group A and group B(P>0.05). After 2 years of follow-up, the loss rate of follow-up of the parturients in group C was 3.3%, and that of the parturients in group D was 1.3%. The proportion of refertility intention of the parturients in group A was slightly higher than that of the parturients in group B, but which of the parturients had no significant different between group A and group B(P>0.05). In group D, the success rate(91.9%) of the parturients with analgesia during induction of labor was significantly higher than that(80.6%) of the parturients without analgesia during induction of labor. The maternal and infant conditions of the parturients with re-pregnancy, there were no significant differences in the proportion of different delivery mode and the neonatal Apgar score of the parturients between group A and group B(P>0.05), and the neonatal weight(3478.6±229.7g) in group A  was significantly lower than that(3610.3±247.2g) in group B(P<0.05). Conclusion: Analgesia by continuous epidural anesthesia epidural for treating the primiparas with the second trimester of pregnancy during induction of labor can effectively reduce their pain and postpartum bleeding amount, which has little effect on the prognosis of mothers and infants of the primiparas with short-term re-pregnancy.