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| Effects of esketamine for postoperative analgesia of obese parturient on their pain control and depression after cesarean section |
| Wuhu First People's Hospital, Wuhu, Anhui Province, 241000 |
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Abstract To investigate the effects of esketamine for postoperative analgesia of obese parturient(BMI ≥ 30 kg/m2) on their pain control and depression after cesarean section. Methods: A total of 82 obese parturients who had undergone cesarean section were selected and randomly divided into two groups(41 cases in each group) from January 2020 to December 2021. The parturients in the research group were given 45mg estazolam combined with 50μg sufentanil and 10mg azasetron for postoperative analgesia, and the parturient in the control group were given 100μg sufentanil combined with 10mg azasetron for postoperative analgesia. All the parturient were followed up for 8 weeks after operation. The intraoperative related indicators, the NRS analgesic score, the postpartum depression score(EPDS), the analgesic-related adverse reactions, the sleep quality, the postpartum anxiety, and the recovery quality of the parturient in the two groups were observed. Results: All 82 parturient had completed the follow-up. There were no significant differences in the operation time, the anesthesia duration, and the intraoperative blood loss of the parturient between the two groups(P>0.05). The resting NRS scores of the parturient in the research group at 2h, 6h, 12h, 24h, and 48h after operation were significantly lower than those of the parturient in the control group, and the locomotor NRS scores of the parturient in the research group at 6h, 12h, 24h and 48h after operation were also significantly lower than those of the parturient in the control group. The EPDS scores of the parturient in the research group in 1, 3, 6 and 8 weeks after operation were significantly lower than those of the parturient in the control group(all P<0.05). Compared with those of the parturient in the control group, the parturient in the research group had better sleep quality, lower GAD-7 score(5.73±2.16 points vs. 7.49±2.58 points), and higher QOR-15 score(122.47±29.51 points vs. 108.45±25.66 points)(all P>0.05). Conclusion: Esketamine can reduce the postoperative pain degree of the obese parturient, relieve their postpartum depression, and promote their recovery quality, with good safety.
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