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| Relationship between body mass index (BMI) and serum iron metabolism level of pregnant women with gestational diabetes mellitus and their insulin resistance |
1. Qiongshan District Maternal and Child Health Care Hospital of Haikou, Haikou, Hainan Province, 570100；
2.Haikou Hospital Affiliated to Xiangya School of Medicine, Central South University, Haikou |
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Abstract To study the relationship between body mass index (BMI) and serum iron metabolism level of pregnant women with gestational diabetes mellitus (GDM) and their homeostasis model assessment of insulin resistance (HOMA-IR) value. Methods: 142 pregnant women with GDM were selected in observation group and 108 normal pregnant women were selected in control group from May 2018 to November 2020. The BMI of the women in the two groups was measured in the first prenatal examination during 12 gestational weeks and in the time of GDM confirmation (24-28 gestational weeks), the levels of serum iron metabolism index, blood glucose, and insulin of the women in the two groups were detected. The HOMA-IR values of the women in the two groups were calculated. The relationship between BMI and serum iron metabolism level of the women in the observation group and their insulin resistance was analyzed. Results: The values of body weight and BMI of the women in the two groups during the second and third trimester of pregnancy were significantly higher than those before pregnancy, and which of the women in the observation group were significantly higher than those of the women in the control group. The serum iron level (14.12±4.67μmol/L) and serum ferritin level (177.45±35.35μg/L) of the women in the observation group were significantly higher than those (9.85±3.12 μmol/L and 127.36±40.33) of the women in the control group. The levels of fasting blood glucose and fasting insulin, and the HOMA-IR value of the women in the observation group were significantly higher than those of the women in the control group (all P＜0.05). The BMI value and serum iron level of the women during pregnancy were positively correlated with their HOMA-IR value (P＜0.05). The predictive efficacy of serum ferritin level of the women for their GDM was the highest, with a sensitivity of 93.7% and a specificity of 74.1%. Conclusion: The abnormal increase of body mass and the increase of serum iron metabolism of the pregnant women may be all aggravate their insulin resistance, and which lead to impaired glucose tolerance and GDM. The increase of iron reserve of the pregnant women also has a relationship with their insulin resistance. The serum ferritin level of the pregnant women has certain predictive value for their GDM. It is suggested that the body mass value of the pregnant women should be controlled to keep stable, and their iron load should be reduced, so as to prevent the occurrence of GDM.
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