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Abstract To investigate the correlation between the levels of serum vitamin B12 (VitB12) and homocysteine (HCY) of pregnant women and their hypothyroidism. Methods: 130 pregnant women with hypothyroidism were selected and were divided into group A (56 women with clinical hypothyroidism during pregnancy) and group B (74 women with subclinical hypothyroidism during pregnancy) according to the results of thyroid function examination from February 2020 to February 2022. Another 60 women with normal thyroid function during pregnancy were selected in group C. The levels of fasting blood glucose (FBG), 2h postprandial blood glucose (2 h PG), total cholesterol (TC), three acyl glycerol (TG), low density lipoprotein (LDL-C), and high density lipoprotein (HDL-C), thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), VitB12, and Hcy of the women were compared among the three groups. Person correlation was used to analyze the correlation between the levels of VitB12 and HCY of the women and their thyroid function indexes levels. The women were also divided into 110 cases with adverse pregnancy outcomes in group D and 20 cases with normal pregnancy outcomes in group E according to the pregnancy outcomes of the women, and the VitB12 and HCY levels were compared between the two groups. Results: The levels of serum FBG, 2h PG, TC, TG, LDL-C, TSH, and HCY of the women in group A, group B, and group C had decreased in turn, while the levels of HDL-C, FT3, FT4, and VitB12 had increased in turn (all P＜0.05). There was no correlation between the VitB12 of the women in group A and group B and their levels of TSH, FT3, and FT4 (P＞0.05). The HCY level of the women in group A and group B was positively correlated with their TSH level (P＜0.05), but which was negatively correlated with their FT3 and FT4 levels (P＜0.05). The incidence of gestational hypertension of the women in group A and group B (32.1% vs. 32.4%) had no significant different, but which of the women in group A and group B was significantly higher than that (5.0%) of the women in group C. The incidence of gestational diabetes (12.5% vs. 10.8%) had no significant different, but which of the women in group A and group B was significantly higher than that (0) of the women in group C (all P＜0.05). The incidence of adverse pregnancy outcomes of the women in group A or group B was 83.93% or 85.14%, which was significantly higher than (18.3%) of the women in group C (P＜0.05). The VitB12 level of the women in group D was significantly lower than that of the women in group E, and the HCY level of the women in group D was significantly higher than that of the women in group E (all P＜0.05). Conclusion: The serum VitB12 level of the pregnant women with gestational hypothyroidism decreases, and their HCY level increases, both of which may be involved in the occurrence and development of gestational hypothyroidism and are closely related to their adverse pregnancy outcomes.
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