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| Expression of the serum carbohydrate antigen 125, progesterone, and anti-Müllerian hormone levels of women with ectopic pregnancy and their value for predicting drug treatment efficacy |
| Xuancheng People's Hospital, Anhui Province, 242000 |
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Abstract To analyze the values of the levels of serum carbohydrate antigen 125 (CA125), progesterone (P), and anti-Müllerian hormone (AMH) for diagnosing ectopic pregnancy and for predicting the drug treatment efficacy. Methods: 76 women with ectopic pregnancy who had been diagnosed and treated were selected in study group, and 76 healthy pregnant women who received physical examination were selected in control group from October 2019 to October 2021. The levels of serum CA125, P, and AMH of the women in the two groups were detected. The women in the study group were divided into group A (women with effectively drug treatment) and group B (women without effectively drug treatment) according to the efficacy of drug after 1 month treatment. Receiver operating characteristic (ROC) curve was drawn to evaluate the values of the serum CA125, P, AMH levels for diagnosing ectopic pregnancy and for predicting the therapeutic efficacy. Results: The level of serum CA125 (32.57±4.31 IU/ml) of the women in the study group was significantly higher than that (26.74±3.78 IU/ml) of the women in the control group. The levels of AMH (106.71±10.26 ng/ml) and P (31.75±3.89 ng/ml) of the women in the study group were significantly lower than those (115.62±12.14 ng/ml and 35.49±4.21 ng/ml) of the women in the control group (all P<0.05). ROC curve showed that the sensitivity and specificity of the CA125 level for diagnosing ectopic pregnancy were the highest, and the sensitivity of AMH level for diagnosing ectopic pregnancy was significantly higher than that of P level, while the specificity of AMH level for diagnosing ectopic pregnancy was significantly lower that of P level. The diagnostic value of the combination of the levels of CA125, AMH, and P was the highest, and the area under the curve of which was 0.953. After 1 month of treatment, 61 (80.3%) women in the study group had effectiveness. The serum CA125 level of the women in group A was significantly lower than that of the women in group B, and the serum AMH and P levels of the women in group A were significantly higher than those of the women in group B (all P<0.05). ROC curve showed that the sensitivity of the serum P level for predicting the treatment effect was the highest, the specificity of the CA125 level for predicting the treatment efficacy was the highest. The combination of the levels of CA125, AMH, and P had the highest value for predicting the treatment efficacy, the area under the curve of which was 0.958. Conclusion: The level of serum CA125 of the women with ectopic pregnancy increase abnormally, and their levels of AMH and P decrease abnormally. The levels of serum CA125, AMH, and P are all the effective indicators for diagnosing ectopic pregnancy and predicting the efficacy of drug treatment. The combined detection of the levels of serum CA125, AMH, and P can improve the value of clinical guidance.
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