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| Changes of the blood lipid metabolism, and the levels of peripheral blood soluble vascular growth factor receptor-1 and soluble endothelial factor of women with preeclampsia and their correlation with the preeclampsia |
| Pidu District Maternal and Child Health and Family Planning Service Center of Chengdu (Pidu District Maternity and Child Health Care Hospital of Chengdu), Chengdu, Sichuan Province, 611730 |
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Abstract To explore the changes of the blood lipid metabolism and the levels of peripheral blood soluble vascular growth factor receptor-1 (sFlt-1) and soluble endothelial factor (sEng) of pregnant women with preeclampsia (PE), and to analyze the correlation between the blood lipid metabolism of the women with their PE. Methods: A total of 124 pregnant women with PE were selected in study group and 117 normal pregnant women were enrolled in control group between January 2019 and January 2021. The blood lipid metabolism indicators and the levels of peripheral blood sFlt-1 and sEng of the women were compared between the two groups, and among the women with different clinical types of PE. Results: The levels of serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), sFlt -1, and sEng of the women in the study group were significantly higher than those of the women in the control group, while the levels of serum high density lipoprotein cholesterol (HDL-C) and apolipoprotein A (ApoA) of the women in the study group were significantly lower than those of the women in the control group. The levels of serum TC, TG, LDL-C, sFlt, and sEng of the women with severe PE were significantly higher than those of the women with mild or moderate PE, and the levels of serum TC, TG, LDL-C, sFlt -1, and sEng of the women with late onset PE were significantly lower than those of the women with PE early onset PE (all P<0.05). Multiple linear regression analysis showed that the levels of sFlt-1 and sEng of the women with PE were positively correlated with their levels of TC, TG, and LDL-C (P<0.05), but which had no correlation with their levels of HDL-C and ApoA (P>0.05). Conclusion: The pregnant women with EP have abnormal blood lipid metabolism and the elevated peripheral blood sFlt-1 and sEng levels. The blood lipid metabolism indicators of the pregnant women with EP are correlated with their sFlt-1 and sEng levels, and which may be involved in the occurrence and development of their PE.
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| Cite this article: |
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XIAO Xuehong. Changes of the blood lipid metabolism, and the levels of peripheral blood soluble vascular growth factor receptor-1 and soluble endothelial factor of women with preeclampsia and their correlation with the preeclampsia[J]. 中国计划生育学杂志, 2022, 30(7): 1631-.
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| URL: |
| https://www.zgjhsyx.com/EN/ OR https://www.zgjhsyx.com/EN/Y2022/V30/I7/1631 |
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