|
Abstract To analyze the high risk factors of abnormal lipid metabolism of pregnant women with gestational diabetes mellitus (GDM) and normal pre-pregnancy body mass index (BMI), and to study their predictive value. Methods: From October 2018 to October 2020, 167 pregnant women with GDM and normal pre-pregnancy BMI were selected in observation group, and 180 pregnant women with normal glucose tolerance were selected in control group. According to the occurrence of abnormal lipid metabolism, the pregnant women in the observation group were further divided into group A (53 women with abnormal lipid metabolism) and group B (114 women with normal lipid metabolism). The incidence and high risk factors of abnormal lipid metabolism of the pregnant women with GDM were analyzed. The predictive value of clinical indicators of the pregnant women with GDM during the first trimester of pregnancy for their abnormal lipid metabolism was explored. Results: The incidence of abnormal lipid metabolism (30.5%) of the women in the observation group was significantly higher than that (6.1%) of the women in the control group (P<0.001). The proportions of age ≥40 years old, multiple fetus, polycystic ovary syndrome (PCOS), hypertensive disease during pregnancy, poor blood glucose control, and GDM with abnormalities of 3 items, and the levels of fasting insulin, thyroid stimulating hormone, serum transferring, and triglyceride of the women in group A were significantly higher than those of the women in group B (all P<0.05). There were no significant differences in the gravidity, the proportions of parturient women and the women with assisted reproductive technology, and the levels of serum total cholesterol, high density lipoprotein, and low density lipoprotein of the women between the two groups (all P>0.05). Age ≥40 years old, PCOS, hypertensive disease during pregnancy, poor blood glucose control, and abnormal elevation of the levels of serum fasting insulin, thyroid stimulating hormone, and transferrin of the pregnant women with GDM were the independent risk factors of their abnormal lipid metabolism (P<0.05). The levels of fasting insulin and serum transferrin of the pregnant women with GDM had predictive efficacy for their abnormal lipid metabolism (P<0.05), the area under the curve of which were 0.861 and 0.894, and the cut-off values of which were 12.8mU/L and 447.95mg/dl. Conclusion: The incidence of abnormal lipid metabolism of the pregnant women with GDM and normal pre-pregnancy BMI is still higher than that of the normal pregnant women, which should be paid more attention to in clinic. Some clinical indicators of the women during the first trimester of pregnancy can help predicting the risk of their abnormal lipid metabolism.
|
|
|
|
|
|
