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| Correlation between the levels of fatty acid binding protein 4 and monocyte chemoattractant protein-1 of women with polycystic ovary syndrome and their sex hormone level and lipid metabolism |
| Qingdao Jiaozhou Central Hospital, Jiaozhou, Shandong Province, 266300 |
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Abstract To study the correlation between the levels of fatty acid binding protein 4 (FABP4) and monocyte chemoattractant protein-1 (MCP-1) of women with polycystic ovary syndrome (PCOS) and their sex hormone level and their lipid metabolism. Methods: 119 women with PCOS were selected in study group and 107 healthy women underwent health examination were selected in control group from Jan 2020 to May 2021. The levels of FABP4 and MCP-1, the levels of sex hormones, such as luteinizing Hormone (LH)/Follicle Stimulating Hormone (FSH), testosterone (T), estradiol (E2), and prolactin (PRL), and the levels of the lipid metabolism indexes, such as total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C), of the women were compared between the two groups. The correlations between the levels of FABP4 and MCP-1 of the women with PCOS and their sex hormone level and their lipid metabolism were analyzed. Results: The levels of FABP4 (23.67±5.74 ng/ml) and MCP-1 (107.46±18.35 ng/L) of the women in the study group were significantly higher than those (8.52±2.31 ng/ml and 59.72±10.57 ng/L) of the women in the control group, and the LH/FSH value and the T level of the women in the study group were significantly higher than those of the women in the control group (all P<0.05). There were no significant differences in the E2 and PRL levels of the women between the two groups (P>0.05). The serum TG level of the women in the study group was significantly higher than that of the women in the control group, and the HDL-C level of the women in the study group was significantly lower than that of the women in the control group (all P<0.05), but there were no significant differences in the TC and LDL-C levels of the women between the two groups (P>0.05). Spearman correlation analysis showed that the levels of FABP4 and McP-1 of the women were positively correlated with their LH/FSH value and their T and TG levels, while were negatively correlated with their HDL-C level (all P<0.05). Conclusion: The expressions of serum FABP4 and McP-1 of the pregnant women with PCOS increase abnormally, which are related to the levels of their sex hormone and lipid metabolism indexes, and can be used to reflect the changes of their sex hormone and lipid metabolism indexes levels.
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