To analyze the effect of hot compress of bean bag combined with acupuncture and acupoint massage for labor analgesia of primiparae, and to study its influence on the stage of labor. Methods: A total of 400 primiparae were selected in this study from January 2018 to January 2020. These primiparae were divided into two groups (200 cases in each group) by random number table method. The primiparae in control group received acupuncture and acupoint massage for analgesia, and the primiparae in observation group received acupuncture and acupoint massage combined with hot compress of bean bag for analgesia. The labor duration, analgesic effect, and uterine contraction intensity of the primiparae, and the neonatal conditions were compared between the two groups. Visual analogue scale (VAS) and the general comfort questionnaire (GCQ) were used to evaluate the pain degree and the comfort level of the primiparae in the two groups. Results: The time of the first stage of labor, the second stage of labor, or the total labor of the primiparae in the observation group were significantly shorter than that of the primiparae in the control group. The total effective rate of analgesia (93.0%) of the primiparae in the observation group was significantly higher than that (82.0%) of the primiparae in the control group, and the uterine contraction intensity of the primiparae in the two groups had increased after 30min of analgesia, and which (81.32±26.79mmHg) of the primiparae in the observation group was significantly higher than that (57.89±17.45mmHg) of the primiparae in the control group. VAS scores of the primiparae in the observation group at analgesia 30min (5.27±1.04 points), analgesia 60min (4.68±0.53 points), and analgesia 120min (4.13±0.59 points) of the primiparae in the observation group were significantly lower than those (6.76±0.72 points, 6.15±0.48 points, and 5.77±0.62 points) of the primiparae in the control group  (all P<0.05). As for GCQ evaluation, the scores of psychophysiology  (20.72±4.63 points) and physiology (21.21±4.75 points) of the primiparae in the observation group were significantly higher than those (17.71±4.38 points and 15.89±4.59 points) of the primiparae in the control group (P<0.05). There was no significant difference in 1 min Apgar score of the newborns between the two groups (P>0.05). Conclusion: Hot compress of bean bag combined with acupuncture and acupoint massage for the primiparae during delivery is beneficial to shorten their stage of labor, enhance their uterine contraction intensity, effectively reduce their labor pain, and improve their comfort level, which is worthy of application and promotion in clinical practice.