Abstract To investigate the effects of Kuntai capsule for treating patients after laparoscopic ovarian cyst removal on their ovarian function and inflammatory factors levels. Methods: 124 patients after laparoscopic ovarian cyst removal were selected and were randomly divided into two groups (62 cases each group) from August 2019 to August 2020. The patients in study group were given Kuntai capsule for 3 months (4 capsules per time, 3 times per day), and the patients in control group were given placebo for 3 months during the same time. The blood of the patients in the two groups was collected on the 2nd to 3rd day of menstruation before surgery, and in the 1st and 3rd month after surgery for detecting the levels of estradiol(E2), luteinizing hormone (LH), follicle stimulating hormone (FSH), anti-Müllerian hormone (AMH), interleukin-21(IL-21), and tumor necrosis factor-a (TNF-a) of the patients in the twogroups. Antral follicle count (AFC) in the ovary with ovarian cyst of the patients was measured by ultrasound in the 3rd to the 5th day after menstruation, and was compared between the two groups. The situation of menstruation of the patients within 3 months after surgery was observed and was compared between the two groups. Results: 1 month after surgery, the levels of E2 and AMH, and the AFC of the patients in both groups were significantly lower than those before surgery, while the levels of FSH and LH of the patients in both groups were significantly higher (P<0.05), and which of the patients had no statistically significant differences between the two groups (P>0.05). 3 months after surgery, the levels of E2, FSH, LH, and AMH, and AFC of the patients in the observation group returned to their preoperative levels (P<0.05), while which of the patients in the control group did not return to their preoperative levels (P>0.05), and which of the patients in the observation group were significantly better than those of the patients in the control group (P<0.05). 1 month after surgery, the levels of IL-21 and TNF-a of the patients in both groups were significantly lower than those before surgery, and which of the patients had no statistically significant differences between the two groups (P>0.05). 3 months after surgery, the levels of IL-21 and TNF-a of the patients in the observation group returned to their preoperative levels (P<0.05), and which of the patients in the observation group were significantly lower than those of the patients in the control group (P<0.05), while which of the patients in the control group did not return to their preoperative levels (P>0.05). Pearson correlation analysis showed that the IL-21 and TNF-A levels of the patients were positively correlated with their FSH and LH levels, but were negatively correlated with their E2 and AMH levels. The cumulative incidences of abnormal menstrual cycle frequency, oligomania, and total abnormal menstruation of the patients within 3 months after surgery in the observation group were significantly lower than those of the patients in the control group (all P<0.05). Conclusion: Kuntai capsule would improve the recovery of the impaired ovarian function of the patients by decreasing their levels of postoperative inflammatory factors, which is conducive to reduce menstrual abnormality.
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