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| Correlation between serum coagulation index expression level of pregnant women and their pregnancy induced hypertension |
| 1.The 941 Hospital of Service Support Force, Xining, Qinghai Province, 81000；2. The Third People's Hospital of Xining, Qinghai Province |
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Abstract To explore the correlation between the values of serum prothrombin time（PT), activated partial thrombin time（APTT), fibrinogen（FIB), D-dimer, and blood platelet parameters of pregnant women and their pregnancy induced hypertension (PIH). Methods: From January 2018 to December 2019, 80 pregnant women with PIH were selected in study group, and 80 healthy pregnant women who received routine prenatal examination were randomly selected in control group. The platelet parameters and serum coagulation function indexes of the women in the two groups were detected, and the correlation between the levels of the platelet parameters and serum coagulation function indexes of the women and their situation of PIH was analyzed. Results: The values of mean platelet volume (MPV) and platelet distribution width (PDW), and the levels of FIB and D-dimer of the women in the study group were significantly higher than those of the women in the control group, while the serum PT and APTT levels of the women in the study group were significantly lower than those of the women in the control group (all P<0.05). There was no significant difference in the platelet (PLT) count of the women between the two groups (P>0.05). The values of MPV and PDW, and the levels of FIB and D-dimer of the women with PIH were positively correlated with the severity of their PIH (r=0.529, 0.478, 0.554, 0.551, P<0.05), and the PT and APTT levels of the women with PIH were negatively correlated with the severity of their PIH (r=-0.574, -0.625, P<0.05). Multivariate logistic stepwise linear regression analysis showed that the increased FIB and D-dimer levels were the independent risk factors of PIH (P<0.05). Receiver operating characteristic curve analysis showed that the area under the curve (AUC) and the critical value of the FIB level for diagnosing PIH were 0.824 and 3.85g/L, while the AUC and the critical value of the D-dimer level for diagnosing PIH were 0.821 and 0.27mg/L. Conclusion: The platelet parameters and coagulation function indexes of the pregnant women with PIH are closely related to the severity of PIH, and the levels of FIB and D- dimer of the women can be used as the serological indexes for diagnosing PIH early.
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