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Abstract To explore the relationship between the body composition value and serum adipokines level of women and their polycystic ovary syndrome (PCOS) occurrence. Methods: 65 women with PCOS were selected in study group, and 55 healthy women were randomly selected in control group. The body composition value, and the levels of serum adiponectin (ADP), plasminogen activator inhibitor type-1(PAI-1), neutrophil gelatinase-associated lipocalin (NGAL), sex hormones, blood lipids (BL), and fasting blood glucose (FBG) of the women in the two groups were detected. And statistically analysis was conducted. Results: The levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), total testosterone (TT), low density lipoprotein (LDL-C), apolipoprotein B(ApoB), apolipoprotein A1(ApoA1), and the values of body mass index (BMI), body fat, and visceral fat of the women in the study group were significant higher than those of the women in the control group. The levels of serum high density lipoprotein (HDL-C), ApoA1, and ADP of the women in the study group were significant lower than those of the women in the control group (all P<0.05). Correlation analysis showed that homeostasis model assessment - insulin resistance (HOMA-IR) value of the women was positively correlated with their values of BMI, waist-hip ratio (WHR), visceral fat area, and body fat content, but was negatively correlated with their serum ADP level. Logistic regression analysis showed that HOMA-IR value (aOR=1.800, 95%CI 1.051-3.083), ADP (AOR=0.032, 95%CI 0.001-0.992), visceral fat area (aOR=1.039, 95%CI 1.007-1.079), and skeletal muscle (aOR=0.665, 95%CI 0.457-0.947) were the independent influencing factors for PCOS after adjusted age and BMI value. Conclusion: The visceral fat area and serum ADP level are the independent predictors of PCOS. The visceral fat area may promote the occurrence and development of PCOS by IR. The mechanism of serum ADP participating in PCOS may be related to IR. ADP level can used as a serological marker of the diseases related to IR.
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