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| Analysis of the characteristics of lipid metabolism of pregnant women with gestational diabetes mellitus after delivery and its influencing factors |
| People's Hospital of Lishui District, Nanjing City, Jiangsu Province, 211200 |
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Abstract To analyze the characteristics of postpartum lipid metabolism of pregnant women with gestational diabetes mellitus (GDM), and to study its influencing factors. Methods: 164 pregnant women with GDM were selected in study group, and 160 pregnant women with normal glucose tolerance were selected in control group from January 2018 to October 2019. According to blood lipid indexes of the women in postpartum 6-8 weeks, the women in the study groups were further divided into group A (women with hyperlipidemia) and group B (women with normal blood lipid metabolism). The levels of blood lipid metabolism indexes of the women in postpartum 6-8 weeks were compared between the study group and the control group. The risk factors of postpartum hyperlipidemia of the women with GDM were analyzed. Results: The levels of total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL) of the women in the study group at delivery, and in 6 to 8 weeks after delivery were significantly higher than those of the women in the control group, while high density lipoprotein (HDL) level of the women in the study group was significantly lower than that of the women in the control group (P<0.05). The age, the proportion of poor blood glucose control, and the postpartum body mass index (BMI) value of the women in group A were significantly higher than those of the women in group B (P<0.05). There were no significant differences in the value of gestational weight gain, the proportion of primiparas, the insulin treatment rate, the gestational weeks at delivery, and the BMI value at enrollment in this study, and the newborn birth weight of the women between group A and group B (P>0.05). The levels of TC, TG, LDL, and 2h blood glucose level of oral glucose tolerance test (OGTT) of the women in group A were significantly higher than those of the women in group B (P<0.05), and there were no significant differences in the levels of HDL, FPG, and 1 h blood glucose of OGTT of the women between group A and group B (P>0.05). The postpartum BMI value, the poor blood glucose control, the abnormal increase of the levels of TC and TG during delivery, and 2h blood glucose level of OGTT during pregnancy were the independent risk factors of postpartum hyperlipidemia of the pregnant women with GDM (P<0.05). Conclusion: In postpartum 6-8 weeks, the women with GDM still has abnormal lipid metabolism, especially for those women with obese, with poor blood glucose control during pregnancy, and with the high levels of TC and TG during delivery, or with the high 2h blood glucose level of OGTT during pregnancy have the high risk of postpartum hyperlipidemia.
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