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| Effects of nalbuphine hydrochloride injection on the analgesic effect, depression, and recovery situation of women after cesarean section |
| Port Hospital, Hebei Port Group Co. Ltd, Qinhuangdao, Hebei Province, 066002 |
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Abstract To investigate the effects of nalbuphine hydrochloride injection on the analgesic effect, depression, and recovery situation of women after cesarean section. Methods: From June 2019 to June 2020, 120 pregnant women who wanted cesarean section were randomly selected and were divided into two groups (60 cases in each group). Nalbuphine hydrochloride injection was given to the women in the observation group for postoperative analgesia, and sufentanil was given to the women in the control group for postoperative analgesia. The postoperative analgesic effect, the depression mood situation, the inflammatory factors levels, and the adverse reactions rate of the women after cesarean section were compared between the two groups. Results: The visual analogue scale (VAS) score of analgesia of the women in the observation group at 6h after analgesia (2.27±0.58 points), 24h after analgesia (1.74±0.52 points), and 48h after analgesia (0.96±0.36 points) were significantly lower than those (3.18±1.21 points, 2.41±2.15 points, and 2.02±1.17 points) of the women in the control group. The score (3.87±0.44 points) by Postpartum Edinburgh Postpartum Depression Scale (EPDS) of the women in the observation group was significantly lower than that (5.78±0.41 points) of the women in the control group. The levels of serum interleukin-6 and C-reactive protein of the women in the observation group at 24h and 48h after analgesia were significantly lower than of the women in the control group, and the incidence of adverse reactions (8.3%) of the women in the observation group was significantly lower than that (23.3%) of the women in the control group (all P<0.05). Conclusion: Nalbuphine hydrochloride injection after cesarean section has better postoperative analgesic effect of the women, can improve their depression and reduce their inflammatory response, and which can also improve their recovery after cesarean section.
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