|
|
|
| Research progress of stem cell for treating Asherman syndrome |
| Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100006 |
|
|
|
|
Abstract This article reviews the newest evidences of stem cell for treating Asherman syndrome. Stem cells are involved in the regulation of fertility and fibrosis related to Asherman syndrome. Stem cells can promote the repair and regeneration of damaged endometrium by multiple mechanism, such as homing to the injured site，recruiting other cells by secreting chemokines, regulating the immune response, and improving the potential antibacterial activity and differentiation into terminal cells or proliferation into daughter cells, etc. This article also discusses the different sources of stem cells and the curative effect of their ways of administration. In rodent models，the stem cells injecting in the whole body systemically can regenerate endometrium more effectively than that of intrauterine injection. The bone marrow-derived stem cells have wider differentiation potential, which play a stronger role in uterine regeneration than that of uterine-derived stem cells. In addition, clinical trials have preliminarily demonstrated that the stem cells derived from menstruation, bone marrow, umbilical cord, or adipose tissue have the safety and the efficacy in the recovery of menstruation, the fertility outcomes, and the endometrial regeneration.
|
|
|
|
|
|
|
|
|
