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| Serum A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) and ADAMTS9 expressions of patients after uterine myomectomy and its correlation with the prognosis |
| 1. Hospital of Liaoning Armed Police Corps，Shenyang, Liaoning Province, 110034; 2. Shengjing Hospital of China Medical University（Yongsen hospital)，Shenyang |
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Abstract To investigate the expressions of serum A disintegrin and metalloproteinase with thrombospondin motifs 1（ADAMTS1）and ADAMTS9 of patients after uterine myomectomy，and to study the correlation between the ADAMTS1 and ADAMTS9 levels of the patients and their prognosis after uterine myomectomy. Methods：137 patients who had undergone uterine myomectomy from March 2019 to October 2020 were selected in research group，and 137 patients with normal uterus who had accepted the healthy physical examination were selected in control group during the same period. Enzyme-linked immunosorbent assay was used to detect the levels of serum ADAMTS1 and ADAMTS9 of the patients on the 7th day after operation. The patients were followed up for 1 year, 28 cases with the recurrence of myoma of uterus were in group A and 109 cases without the recurrence of myoma of uterus were in group B. Logistic regression was used to analyze the risk factors affecting the postoperative recurrence of myoma of uterus. Receiver operating characteristic（ROC）curve was used to analyze the values of the postoperative levels of serum ADAMTS1 and ADAMTS9 for predicting the postoperative recurrence of myoma of uterus. Results：The levels of serum ADAMTS1 and ADAMTS9 of the patients in the research group before operation were significantly higher than those of the patients in the control group, but which of the patients in the research group after operation were significantly lower than those of the patients in the control group, and which of the patients in group B were significantly lower than those of the patients in group A (all P<0.05). The levels of ADAMTS1 and ADAMTS9 of the patients in the research group after operation were the risk factors of postoperative recurrence of myoma of uterus (P<0.05), and the area under the curve (AUC) of the ADAMTS1 level and ADAMTS9 level of the patients for diagnosing their myoma recurrence were 0.796 (95%CI 0.710-0.882) and 0.791 (95%CI 0.693-0.889), respectively. The AUC, the sensitivity, and the specificity of the combined levels of ADAMTS1 and ADAMTS9 of the patients for diagnosing their myoma recurrence were 0.920 (95%CI 0.873-0.967), 89.3%, and 84.4%, respectively. Conclusion：The levels of serum ADAMTS1 and ADAMTS9 of the patients with myoma of uterus are abnormal, and the increased levels of which are the risk factor of myoma recurrence, and the combined levels of serum ADAMTS1 and ADAMTS9 can provide reference for predicting the postoperative myoma recurrence.
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