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| Value of the levels of serum transferring, laminin, and α1-microglobulin of pregnant women with gestational diabetes mellitus for predicting their early renal injury |
| Guang'an People's Hospital，Guang'an，Sichuan Province, 638000 |
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Abstract To explore the expression levels of peripheral blood transferring (TRF)，laminin (LN),and α1-microglobulin (α1-MG) of pregnant women with gestational diabetes mellitus (GDM), and to study their values for predicting the early renal injury of these women. Methods: 135 pregnant women with GDM were selected and were divided into group A (women with renal injury) and group B (women without renal injury) according to the occurrence of renal injury between October 2019 and October 2021. In addition，46 healthy pregnant women who had undergone antenatal examination during the same period were enrolled in group C. The baseline data, and the expression levels of TRF，LN, and α1-MG, and the renal function indicators levels at admission of the women were compared among the three groups. The differences of the expression levels of TRF，LN, and α1-MG, and the renal function indicators of the women in the three groups were analyzed. Receiver operating characteristic（ROC）curve was applied to analyze the diagnostic value of the levels of TRF，LN, and α1-MG of the women with GDM for their early renal injury. Results: The serum TRF level and the values of renal function indexes of the women in group A, group B, and group C had decreased gradually, but the LN and α 1-Mg levels of the women in group A, group B, and group C had increased gradually (all P<0.05). Pearson correlation analysis showed that the serum TRF level of the pregnant women with GDM and renal function injury was negatively correlated with their renal function indexes values, and the levels of LN and α 1-Mg levels the pregnant women with GDM and renal function injury were positively correlated with their renal function indexes values (all P<0.05). ROC results showed that the area under of the curve (AUC) of the serum TRF level, LN level, α 1-MG level, or the combination of the levels of TRF, LN, α 1-MG of the women with GDM for diagnosing their early renal function injury were 0.866, 0.625, 0.906, or 0.975, respectively, and the combination of the levels of TRF, LN, α 1-MG had the higher diagnostic value for early renal function injury of the women. Conclusion: The expression levels of the serum TRF，LN and α1-MG of the pregnant women with GDM are closely related to their early renal injury，and the combination of the levels of TRF, LN, α 1-MG detection can be used as the serological indicators for early renal injury of the women.
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