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| Correlation between the thyroid stimulating hormone level of women with polycystic ovary syndrome and their gluco lipid metabolism disorder |
| The First Affiliated Hospital of Nanyang Medical College, Henan Province, 473006 |
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Abstract To analyze the correlation between the serum level of thyroid stimulating hormone（TSH）of women with polycystic ovary syndrome（PCOS）and their indexes of glucolipid metabolism. Methods: 224 women with PCOS were selected as the study subjects from March 2018 to August 2020. All of these women were given the detections of thyroid function and glucolipid metabolism indicators. According to the tertiles of TSH level，these women were divided into group A (women with low-level TSH)，group B (women with middle-level TSH) and group C (women with high-level TSH). The correlation between the TSH level of the women and their glucolipid metabolism indexes was analyzed. Results: The incidence of metabolic syndrome (MS) of the women in group A, group B, and group C had increased gradually, the levels of FPG and FINS and the value of homeostasis model assessment of insulin resistance (HOMA-IR) of the women in group A, group B, and group C had also increased gradually (P<0.05). The values of body mass index (BMI) and waist to hip ratio (WHR), and the levels of total cholesterol (TC), triglyceride (TG), and low density lipoprotein (LDL) of the women in group C were significantly higher than those of the women in group A and in group B, and the High density lipoprotein (HDL) level of the women in group C was significantly lower (P<0.05). There were no significant differences in the values of BMI and WHR, and the levels of TC, TG, HDL, and LDL of the women between group A and group B (P>0.05). There was no correlation between the serum TSH level of the women with PCOS only and their BMI, WHR, and HOMA-IR values, and their levels of TC, TG, HDL, LDL, fasting blood glucose (FPG), and fasting insulin (FINS) (P>0.05). The TSH level of the women with subclinical hypothyroidism was positively correlated with their TC, TG, FPG, and FINS levels, and their HOMA-IR value (P<0.05). The TSH level of the women with PCOS and subclinical hypothyroidism was positively correlated with their BMI, WHR, and HOMA-IR values, and their levels of TC, TG, LDL, FPG, and FINS, but which was negatively correlated with their HDL level (all P<0.05). The TSH level of the women has predictive value for PCOS complicated with MS (P<0.001), and the area under the curve (AUC), the cut-off value, the sensitivity, and the specificity of which were 0.719, 4.32mIU/L, 69.7%, and 76.2%, respectively. Conclusion: The higher TSH level of the women with PCOS，the higher risk of their MS occurrence. However，the TSH level only in the women with PCOS complicated with subclinical or clinical hypothyroidism is correlated with their glucolipid metabolism indexes.
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