|
|
|
| Changes and clinical significance of serum anti Mullerian hormone，interleukin (IL)-6， IL-8, and tumor necrosis factor alpha levels of women with preterm premature rupture of membranes complicated with intrauterine infection |
| 1. Tongcheng People's Hospital，Hubei Province, 437400; 2. Hubei Xianning Central Hospital of Hubei |
|
|
|
|
Abstract To investigate the serum changes and clinical significance of serum anti Mullerian hormone（AMH)，interleukin (IL)-6， IL-8, and tumor necrosis factor alpha (TNF-α) levels of women with preterm premature rupture of membranes (PPROM) complicated with intrauterine infection. Methods: The clinical data of 86 pregnant women with PPROM from January 2020 to August 2021 were selected in this study. Among them, 47 cases with intrauterine infection were included in group A，and 39 cases without intrauterine infection were included in group B. And these women were also divided in group C (55 cases with premature rupture of membranes time <24h) and group D (31 cases with premature rupture of membranes time≥24h). Another 40 women with preterm birth and intact fetal membranes were selected in control group during the same period. The levels of serum AMH，IL-6，IL-8, and TNF-α of the women were compared among these groups. Results: The serum levels of AMH, IL-6, IL-8, and TNF-α of the women in group A, group B, and group C had decreased gradually (P<0.05). The serum levels of IL-6, IL-8, and TNF-α of the women in group D were significantly higher than those of the women in group C (P<0.05), but there was no significant difference in the AMH level of the women between group C and group D (P>0.05). Spearman correlation analysis showed that the AMH level of the women was correlated with their serum TNF-α level (P<0.05), but was no correlation with their IL-6 and IL-8 levels (P>0.05). The levels of TNF-α, IL-6, and IL-8 of the women were positively correlated (P<0.05). Conclusion: The levels of the serum AMH，IL-6，IL-8, and TNF-α of the pregnant women with PPROM are high expression obviously, and the levels of serum IL-6，IL-8, and TNF-of the women increase with the longer their membrane rupture time and the complicating of intrauterine infection. It is suggested that the levels of the serum AMH，IL-6，IL-8, and TNF-α of the pregnant women may be valuable for early identification of PPROM, especially for those women complicated with intrauterine infection.
|
|
|
|
|
|
|
|
|
