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| Effect of etomidate target controlled infusion combined with naborphine anesthesia during laparoscopic hysteromyoma and its effects on prostaglandin E2 and vascular endothelial growth factor-C |
| 1.Affiliated Hospital of Xiangnan University, Chenzhou, Hunan Province, 423099；2.Clinical College of Xiangnan University |
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Abstract To investigate the effect of etomidate target controlled infusion combined with naborphine anesthesia during laparoscopic surgery of hysteromyoma of the patients, and to study its effects on the levels of the prostaglandin E2 (PGE2) and vascular endothelial growth factor-C (VEGF-C) of the patients. Methods: 102 patients with hysteromyoma who wanted laparoscopic myomectomy were selected and were divided into group A (51 patients were given etomidate target controlled infusion combined with remifentanil anesthesia) and group B (51 patients were given etomidate target controlled infusion combined with naborphine anesthesia) according to different anesthesia methods from March 2020 to March 2021. The curative effects, the operation situation, the levels changes of hemodynamic indexes, PGE2, and VEGF-C, and the rate of adverse reactions of the patients were compared between the two groups. Results: After treatment, the clinical excellence rate (92.2%) of the patients in group B was significantly higher than that (76.5%) of the patients in group A, and the operative time (13.6±9.5min) of the patients in group B was significantly shorter than that (17.5±4.0min) of the patients in group A. The levels of haemodynamics indexes of the patients in group A at 10min, 30min, and 10min after anesthesia were significantly lower than those before anesthesia, and were also significantly lower than those of the patients in group B at 10min, 30min, and 10min after anesthesia (all P<0.05), while which had no significant different from those of the patients in group B at 10min before anesthesia (P>0.05). The levels of PGE2 and VEGF-C (212.39±13.51 pg/ml and 233.46±19.58 pg/ml) of the patients in group B
were significantly lower than those (253.13±19.39 pg/ml and 276.39±25.37 pg/ml) of the patients in group A (P<0.05). The incidence of the adverse reactions (11.8%) of the patients in group B was significantly lower than that (29.4%) of the patients in group A (P<0.05). Conclusion: Etomidate target-controlled infusion combined with naborphine anesthesia during laparoscopic surgery of hysteromyoma of the patients can shorten their operation time, stabilize their hemodynamics, reduce their levels of PGE2 and VEGF-C, with lower adverse reactions rate and better anesthetic effect.
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