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Abstract To analyze the correlation between the parameters measured by antenatal Doppler ultrasound of pregnant women with fetal distress (FD) and their level of hypoxia-inducible factor-1α (HIF-1α), and to study the values of the parameters and the HIF-1αlevel for diagnosing FD of these women. Methods: The clinical data of 105 pregnant women with suspected FD from November 2019 to November 2020 were collected. These women were divided into observation group (60 women with FD) and control group (45 women without FD) according to Apgar score of newborns. The values of the parameters measured by Doppler ultrasound, such as umbilical artery systolic to diastolic blood pressure (S/D), resistance index (RI), pulsatility index (PI), of the women were compared between the two groups. The relationship between the values of S/D, RI, and PI of the women and their erythropoietin (EPO) and β-human chorionic gonadotropin (β-HCG) levels was analyzed. The values of S/D, RI, and PI, and the levels of EPO andβ-HCG for diagnosing FD were also analyzed. Results: The values of S/D, RI, and PI of the women in the observation group were significantly higher than those of the women in the control group, and which of the women with severe FD were significantly higher than those of the women with mild FD. The levels of serum HIF-1α, EPO, and β-HCG of the women with severe FD were significantly higher than those of the women with mild FD (all P＜0.05). The values of S/D, RI, and PI, and the levels of HIF-1α, EPO, and β-HCG of the women were positively correlated with the degree of their FD, and the values of S/D, RI, and PI of the women were positively correlated with their HIF-1α, EPO, and β-HCG levels (all P＜0.05). The value of combined S/D, RI, and PI for diagnosing FD was significantly higher than that of the S/D value, the RI value, or the PI value alone (P＜0.05), the area under the curve and the sensitivity of which were 0.851 and 84.7%. Conclusion: Doppler ultrasound examination has a high diagnostic value for FD, and the S/D, RI, and PI values of the pregnant women with FD are related to their levels of HIF-1α, EPO, and β-HCG. Doppler ultrasound examination can help to clinical diagnosis of FD.
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