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| Value of Logistic regression scoring model of ultrasound examination and the levels of serum vascular endothelial growth factor and sFlt-1 of pregnant women with placenta previa for diagnosing of placenta adhesion and placenta invasion degree of myometrium |
| Pan'an People's Hospital, Zhejiang Province, 322300 |
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Abstract To evaluate the value of Logistic regression scoring model of antenatal ultrasound examination and the levels of serum vascular endothelial growth factor (VEGF) and sFlt-1 of pregnant women with placenta previa for diagnosing their placenta adhesion and their placenta invasion degree of myometrium. Methods: A total of 215 pregnant women with placenta previa who all had accepted color Doppler ultrasound examionation and serum VEGF and sFlt-1 detection, and had the complete clinical examination records from June 2018 to June 2020 were collected retrospectively. These women were divided into group A (172 women without placental attachment or abnormal attachment) and group B (43 women with placental abnormal invasion) according to the postoperative pathological results. Logistic regression analysis was used to construct the regression score model. According to the degree of the placenta invasion, these women were also divided into non-invasive placenta group, PA group, PI group, and PP group. The differences of serum VEGF and sFlt-1 levels of the women were compared among these groups. Receiver operator characteristic curve (ROC) was used to analyze and evaluate the value of the levels of serum VEGF and sFlt-1 of the pregnant women with placenta previa for diagnosing their placenta adhesion and placenta invasion degree of myometrium. Results: Logistic regression score model of antenatal ultrasound examination was lnP/1-P=2.817+ 1.768X1+ 3.625X2-0.559X3-1.823X4+ 3.072X5- 2.785X6. There was no significant difference in the serum VEGF level of the women between group PP and group PI, but there was significant difference in the serum VEGF level of the women among other groups. There was no significant difference in the serum SFLT-1 level of the women between the non-invasive placenta group and group PA, but there was significant difference in the serum SFLT-1 level of the women among other groups (all P＜0.05). The areas under of ROC of the ultrasound examination, serum VEGF level, and serum sFLT-1 level for diagnosing placenta previa adhesion and invasion of myometrium were 0.801, 0.717, and 0.706, respectively, and the diagnostic critical values of which were 5.245, 279.80pg/ml, and 2.66pg/ml, respectively. Conclusion: Prenatal ultrasound Logistic regression score model, and the levels of serum VEGF and sFlt-1 have certain valus for diagnosing their placenta adhesion and their placenta invasion degree of myometrium.
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