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| Clinical effect of loop electrosurgical excision procedure for treating patients with cervical intraepithelial neoplasia and its correlation with their pregnancy outcomes and delivery mode |
| Zhuzhou Central Hospital, Zhuzhou, Hunan Province, 412000 |
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Abstract To analyze the clinical effect of loop electrosurgical excision procedure (LEEP) for treating patients with cervical intraepithelial neoplasia (CIN), and to study its correlation with the pregnancy outcomes and delivery mode of the patients. Methods: 60 patients with CIN from October 2019 to January 2018 were selected retrospectively, and these patients were divided into two groups according to the different cervical operative method. The patients in the experimental group were given LEEP, and the patients in the control group were given cold knife conization (CKC). The operation time, the intraoperative blood loss, the time of hospital stay, the healing time, the pregnancy outcomes, and the delivery mode of the patients were analyzed and were compared between the two groups. The relationships among the operation time, the intraoperative blood loss, the time of hospital stay, the healing time, the pregnancy outcomes, and the delivery mode of the patients were also analyzed. Results: The operative time (7.8±2.2min), the intraoperative blood loss (10.4±1.7ml), the time of hospital stay (5.3±2.5d), and the healing time (28.6±4.3d) of the patients in the experimental group were significantly lower than those of the patients in the control group (P＜0.05). In the experimental group, the pregnancy outcomes of the patients was moderately positively correlated with their operative method (0.551) and their operative time (0.538), and was negatively correlated with their intraoperative blood loss (0.445). In the experimental group, the delivery mode of the patients was moderately positively correlated with their operation time (0.557), their intraoperative blood loss (0.682), and their operative mode (0.556) (all P＜0.05). The independent risk factors of the adverse pregnancy outcomes were operative time, smoking history, abortion history, and number of pregnancy, etc. The incidence of complications (13.3%) of the patients in the experimental group was significantly lower than that (46.7%) of the patients in the control group (P＜0.05). Conclusion: LEEP for treating the patients with CIN can shorten their operative time, reduce their amount of bleeding, accelerate their rehabilitation, reduce their adverse pregnancy outcomes, and improve their delivery mode.
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