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| Value of serum inhibin B, anti-Mullerian tubular hormone, follicle stimulating hormone, and luteinizing hormone levels for predicting the decline of ovarian reserve and the therapeutic effect of ovulation induction evaluated by intracavitary ultrasound |
| 1.Tianshan Hospital of Traditional Chinese Medicine, Changning District, Shanghai, 200051; 2.China Welfare Association International Peace Maternal and Child Health Hospital; 3.Sijing Hospital of Songjiang District, Shanghai |
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Abstract To explore the predictive value of serum inhibin B (INHB), anti-Mullerian tubular hormone (AMH), follicle stimulating hormone (FSH), luteinizing hormone (LH) levels of women for the decline of their ovarian reserve, and to study the therapeutic effect of ovulation induction evaluated by intracavitary ultrasound. Methods: 120 infertility women were selected and were divided into group A (36 women with normal ovarian reserve function) and group B (84 women with the decline of ovarian reserve function) according to their ovarian reserve function from May 2019 to May 2021. The levels of serum INHB, AMH, FSH, and LH of the women in the two groups were detected. Receiver operating curve (ROC) analysis was used to analyze the predictive value of the levels of serum INHB, AMH, FSH, and LH of the women for their decline of ovarian reserve. After ovulation induction treatment of the women with the decline of ovarian reserve, intracavitary ultrasound was used to evaluate the average maximum cross-sectional diameter of the ovary (MOD), peak ovarian interstitial hibernation velocity (PSV), ovarian arterial pulsatility index (PI) and resistance index (RI), antral follicle count (AFC), and the condition of the uterus of the women in the two groups. Results: The serum INHB and AMH levels of the women in group B were significantly lower than those of the women in group A, but the FSH and LH levels of the women in group B were significantly higher (P＜0.05). ROC analysis showed that the levels of serum AMH, INHB, FSH, and LH had certain predictive value for the decline of ovarian reserve function. The combined detection of the levels of serum AMH, INHB, FSH, and LH had the highest predictive value, the area under of ROC, the sensitivity, and the specificity of which were 0.908, 88.1%, and 97.2%, respectively. After ovulation induction treatment of the women with the decline of ovarian reserve, their values of intracavitary ultrasound indicators, such as MOD, AFC, PSV and PI, and their values of uterine volume, endometrial thickness, and mean ovarian volume had increased significantly, while their RI value had decreased significantly. Conclusion: The combined detection of the levels of serum AMH, INHB, FSH, and LH has high value for screening the decline of ovarian reserve early. The intracavitary ultrasound can evaluate the improvement of the uterus and ovary after the therapeutic effect of ovulation induction preferably.
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