Abstract To investigate the influence of bupropion combined with dexmedetomidine for anesthesia induction of patients during laparoscopic myomectomy on their hemorheology and the levels of their endothelin-1 (ET-1) and angiotensin II (Ang II). Methods: 182 patients who wanted laparoscopic myomectomy were selected and simply randomly divided into two groups (91 cases in each group) by the random number table method from January 2020 to December 2020. At 15 min before anesthesia induction, the patients in the observation group were given dexmedetomidine injection (0.5 μg/kg) combined with bupropion injection (0.02 mg/kg), and the patients in the control group were given dexmedetomidine injection (0.5 μg/kg) combined with normal saline (equal amount of bupropion). The levels of ET-1, Ang-II, and fibrinogen, and the values of whole blood specific viscosity, plasma viscosity of the patients at the time of entering room (T0), after induction of anesthesia (T1), 30 min after surgery (T2), and 2 h after surgery (T3) of the patients were compared between the two groups. Results: The values of plasma viscosity and whole blood specific viscosity of the patients in the observation group at T1, T2, and T3 were significantly lower than those at T0, and the fibrinogen level of the patients in the observation group at T1 was significantly higher than those at T0, T2, and T3 (all P＜0.05). The plasma viscosity value of the patients in the observation group at T1, T2, and T3 was significantly lower than that of the patients in the control group, the value of whole blood specific viscosity of the patients in the observation group at T1 and T2 was significantly lower than that of the patients in the control group, and the value of
plasma viscosity of the patients in the observation group at T1 was significantly higher than that of the patients in the control group (all P＜0.05). The levels of ET-1 and ANG-II of the patients in the two groups at T0, T1, T2, and T3 had increased gradually, which of the patients in the observation group at T1, T2, and T3 was significantly lower than that of the patients in the control group (all P＜0.05). The incidence of adverse reactions (25.3%) of the patients in observation group was significantly lower than that (39.6%) of the patients in control group (P＜0.05). Conclusion: Butorphanol combined with dexmedetomidine for anesthesia induction of patients during laparoscopic myomectomy can reduce the adverse influences on their hemodynamics, which can inhibit the increase of ET-1 and Ang II levels, and can decrease the occurrence of postoperative anesthesia-related adverse reactions.
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