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| Effect of goserelin combined with Guizhi fuling capsule for treating women with endometriosis after operation and its influence on the level of their inflammatory factors |
| Dalian Maternal and Child Health Care Hospital, Dalian, Liaoning Province，116033 |
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Abstract To observe the curative effect of goserelin combined with Guizhi fuling capsule for treating patients with endometriosis (EMT) after operation, and to study the changes of serum PG E2 and PG F2α, and TXB2 levels of these patients. Methods: A prospective study was conducted in 88 patients with EMT from September 2018 to April 2019. These patients were randomly divided into observation group and control group (44 cases in each group). The patients in both groups were treated with goserelin after operation for 3 months, and the patients in the observation group were treated with Guizhi fuling capsule additionally for 3 months. The therapeutic effect, the levels of sex hormone, PGE2 ,PGF2α, and TXB2, and the adverse reactions rate of the patients were compared between the two groups. Results: After treatment, the grading score of EMT and the pain score of the patients in the two groups had decreased significantly, and which of the patients in the observation group were significantly lower than those the patients in the control group. The levels of estradiol, luteinizing hormone, follicle stimulating hormone, testosterone, and sex binding globulin of the patients in the two groups had improved significantly after treatment, and which of the patients in the observation group were significantly better than those the patients in the control group. The levels of PGE2, PGF2α, and TXB2 of the patients in the two groups had decreased significantly after treatment, and which of the patients in the observation group were significantly lower than those of the patients in the control group. The recurrence rate (6.8%) of the patients in the observation group during postoperative followed up for 1 year was significantly lower than that (22.7%) of the patients in the control group (all P>0.05). There were no significant differences in the rates of adverse reactions, such as nausea and vomiting, breast swelling, vaginal bleeding, and hot flashes, of the patients between the two groups (P>0.05). Conclusion: Goserelin combined with Guizhi fuling capsule for treating women with EMT after operation can improve their surgical effect, reduce the recurrence of EMT, down-regulate the level of their serum inflammatory factor with better drug safety.
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