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| Analysis of the correlation between MTHFR gene polymorphism of 259 pregnant women and their adverse pregnancy outcomes in Panjin area |
| Liaoyou Baoshihua Hospital, Panjin, Liaoning Province, 124010 |
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Abstract To analyze the correlation between MTHFR gene polymorphism of pregnant women and their adverse pregnancy outcomes in Panjin area of Liaoning province.Methods: 124 women with a history of adverse pregnancy outcomes were selected in observation group, and 135 women without a history of adverse pregnancy outcomes were selected were selected in control group from October 2018 to October 2020.Hardy Weinberg equilibrium test was used to verify the representativeness and reliability of the samples of the women in the two groups.MTHFR genotypes of the women in the two groups were detected, and the genotype frequency, allele frequency and combined genotype frequency of the women were compared between the two groups.Results: Hardy Weinberg equilibrium test showed that the genotypic frequency distribution of the collected population samples of the women in the two groups had reached genetic equilibrium, and all of them were the same Mendelian population.TT frequency of C677T site (32.3%) of the women in the observation group was significantly higher than that (13.3%) of the women in the control group.CC frequency of A1298C site (12.1%) of the women in the observation group was significantly higher than that (2.2%) of the women in the control group.T locus frequency of C677T allele (51.6%) of the women in the observation group was significantly higher than that (30.4%) of the women in the control group, and C locus frequency of A1298C allele of the women in the observation group was significantly higher than that (28.2%) of the women in the control group.The frequencies of CC/CC, CT/CC, TT/AA and TT/AC combined genotype of the women in the observation group were significantly higher than those of the women in the control group (all P＜0.05).Conclusion: MTHFR gene polymorphism is related to the occurrence of adverse pregnancy.Screening MTHFR gene polymorphism and early intervention are of great significance to reduce the incidence of adverse pregnancy and prevent birth defects.
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