To explore the effect of Sanjie zhentong capsules combined with drospirenone and ethinyl estradiol tablets for treating patients with adenomyosis (ADS) on their ovarian reserve and their levels of vascular endothelial growth factor (VEGF), adiponectin (APN), and angiopoietin-2 (Ang-2).Methods: 180 patients with ADS were selected and were randomly divided into 3 groups (60 cases in each group) from February 2019 to February 2021.The patients in group 1 had received Sanjie zhentong capsules, the patients in group 2 had received drospirenone and ethinyl estradiol tablets -Ⅱ, and the patients in group 3 had received Sanjie zhentong capsules combined with drospirenone and ethinyl estradiol tablets-Ⅱ.The uterine volume, the levels of hormone indictors of ovarian reserve function and angiogenesis related factors of the patients were compared among the three groups.Results: After treatment, the uterine volume, the levels of antimullerian hormone, follicle-stimulating hormone, luteinizing hormone, estrogen, VEGF, and APN of the patients in the three groups had decreased to different degrees, while the Ang-2 level of the patients in the three groups had increased to different degrees, the change ranges of which of the patients in group 3 were significantly more than those of the patients in the other two groups (all P＜0.05).The total effective rate (83.3%) of the patients in group 3 after treatment was significantly higher than that (66.7%) of the patients in group 1 and that (65.0%) of the patients in group 2.There was no any patient with obvious adverse reaction in the three groups.Conclusion: Sanjie zhentong capsules combined with drospirenone and ethinyl estradiol tablets for treating the patients with adenomyosis can effectively improve their ovarian reserve, can reduce their levels of VEGF and Ang-2, and can increase their APN level with better effectiveness and safety.