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| Value of the combinational detections of fFN, NF-κB and HMGB 1 for predicting premature delivery and their relevant with neurodevelopment of newborns |
| Weifang Maternal and Child Health Care Hospital, Shandong Province, 261011 |
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Abstract To explore the value of the combination of fetal fibronectin (fFN), nuclear transcription factor (NF-κB), and high mobility group protein B1 (HMGB1) for predicting premature delivery, and to study their relevant with neurodevelopment of newborns. Methods: The clinical data of 195 pregnant women with preterm birth risk factors from January 2019 to April 2020 were collected retrospectively. According to the pregnancy outcomes, these women were divided into group A (51 women with preterm birth) and group B (144 women with term birth).The levels of fFN in vaginal secretions and NF-κB and HMGB1 in serum of the women in the two groups were detected. Receiver operating curve (ROC) was drawn to analyze the predictive value of the levels of fFN in vaginal secretions and NF-κB and HMGB1 in serum for preterm birth. The correlation between neural development of preterm newborns and the expression levels of maternal serum NF-κB and HMGB1 was analyzed. Results: The fFN level in vaginal secretions and the level s of serum NF-κB and HMGB1 of the women in group A within 3, 7 and 14 days after the onset of premature delivery were significant higher than those of the women in group B (P＜0.05).Within 14 days after the onset of premature delivery, the levels of fFN and serum NF-κB and HMGB1 of the women for predicting preterm labor had higher value, with the sensitivity of 80.4% and the specificity of 87.5%. The levels of serum NF-κB and HMGB1 of the newborns with neurodevelopmental dysplasia on the 3rd and the 7th day after born were significant higher than those of the newborns without neurodevelopmental dysplasia (P＜0.05).There was a positive correlation between neurodevelopment of the newborns and their serum NF-κB and HMGB1 levels (P＜0.05). Conclusion: The combined detections of fFN, NF-κB, and HMGB1 levels has high predictive value for premature delivery, and the levels of serum NF-κB and HMGB1 are closely related to the neonatal neurodevelopment. The levels of serum NF-κB and HMGB1 of the premature infants should be detected for evaluating their neurodevelopment and early intervention treatment in clinic.
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