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Abstract To analyze the diagnostic value of the levels of serum interleukin-4（IL-4), interleukin-12（IL-12), interferon-γ(IFN-γ), and tumor necrosis factor-α(TNF-α）of pregnant women for the occurrence and severity of intrahepatic cholestasis of pregnancy（ICP). Methods: The clinical data of 96 pregnant women with ICP in and 80 normal pregnant women from July 2017 to December 2019 were collected retrospectively. According to the severity of ICP, 33 women with severe ICP were divided in group A, 63 women with mild ICP were in group B. The diagnostic values of the levels of serum IL-4, IL-12, IFN-γ, and TNF-α of the pregnant women for their occurrence and severity of ICP were analyzed, and the critical values were calculated. Results: The sensitivity of serum IL-4 level, IL-12 level, IFN-level, and TNF-α for diagnosing ICP were 91.7%, 89.6%, 87.5%, and 90.6%, respectively, and the specificity of them were 88.8%, 86.3%, 85.0%, and 87.5%, respectively. The areas under the curve（AUC）of serum IL-4 level, IL-12 level, and TNF-level were 0.757, 0.703, and 0.706, respectively（P<0.05), and which’s diagnostic critical values were 98.0pg/ml, 18.5pg/ml, and 76.5pg/ml, respectively. The IL-4 level and IL-12 level had certain diagnostic value for the severity of ICP, with AUC of 0.727 and 0.709（P<0.05), and which’s diagnostic critical values were 78.13pg/ml and 27.50pg/ml. Conclusion: The levels of IL-4, IL-12, and TNF-α have a certain diagnostic value for the occurrence of ICP, and the levels of IL-4 and IL-12 also have a certain diagnostic effect for the severity of ICP, so the pregnant women with high-risk ICP should be further detected and treated according to the critical values of diagnosing ICP.
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