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| Correlation between the levels of IL28B-SNP, AMH, and Sp17Ab of patients with poor ovarian response and their susceptibility of hepatitis B virus infection |
| People's Hospital of Rongchang District, Chongqing, 402460 |
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Abstract To analyze the correlation between the levels of IL28B-SNP, AMH, and Sp17Ab of patients with poor ovarian response (POR) and their susceptibility of hepatitis B virus (HBV) infection. Methods: 82 patients with POR complicated with HBV infection were selected in observation group, and the patients with POR were selected in 93 control group from December 2018 to February 2021. The expression of IL28B rs8099917 of the patients in the two groups was detected by PCR. The levels of serum AMH and Sp17Ab of the patients in the two groups were detected by ELISA. Spearman correlation test was used to analyze the relationship between the levels of IL28B-SNP, AMH, and Sp17Ab of the patients with POR and their susceptibility of HBV infection. Logistic regression model was used to analyze the risk factors of HBV infection of the patients with POR. Results: The proportion of IL28B-SNP rs8099917 G mutation (59.8%) of the patients in the observation group was significantly higher than that (37.6%) of the patients in the control group, and the AMH level (3.05±0.29ng/m) of the patients in the observation group was significantly lower than that (4.61±0.32ng/m) of the patients in the control group. The Sp17Ab level (9.57±2.13 U/L) of the patients in the observation group was significantly higher than that (3.28±0.79 U/L) of the patients in the control group (all P＜0.05). The levels of Il28b-SNP and Sp17Ab of the patients with POR were positively correlated with their HBV infection rate, while the AMH level of the patients with POR was negatively correlated with their HBV infection rate (P<0.05). The G mutation of IL28B-SNP rs8099917, the low AMH level, and the high Sp17Ab level of the patients with POR were the risk factors of their HBV infection (P<0.05). Conclusion: G mutation of IL28B-SNP rs8099917, the low AMH level, and the high sp17ab level of the patients with POR are the independent risk factors of their HBV infection. It is suggested to strengthen clinical screening and timely intervention of the patients with POR.
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