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| Effect of combined spinal and epidural anesthesia during cesarean section of pregnant women with chronic hypertension complicating preeclampsia on their coagulation function |
| 95829 Army Hospital, Wuhan, Hubei Province, 430012 |
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Abstract To investigate the effect of combined spinal and epidural anesthesia during cesarean section of pregnant women with chronic hypertension complicating preeclampsia on their coagulation and fibrinolysis system. Methods: 62 pregnant women with chronic hypertension complicating preeclampsia were selected and were divided into two groups (31 cases in each group) by random number table methods from January 2019 to January 2021. The women in the control group received continual epidural anesthesia during cesarean section, while the women in the observation group received combined spinal and epidural anesthesia during cesarean section. The hemodynamics, anesthesia effect, stress response indexes, and coagulation function indexes of the women were compared between the two groups. Results: There were no significant differences in the values of diastolic blood pressure and systolic blood pressure of the women before anesthesia, before operation, before delivery, and at the end of operation between the two groups (P>0.05). The onset time of anesthesia (3.1±0.8 min) and the time to the highest level of anesthesia (7.8±1.8 min) of the women in the observation group were significantly lower than those (6.4±1.7 min and 13.1±2.8 min) of the women in the control group. The dosage of ephedrine (12.2±2.8 mg) of the women in the observation group was significantly higher than that (6.0±1.3 mg) of the women in the control group (P<0.05). The levels of serum aldosterone (107.48±13.21) and cortisol (191.33±18.25) of the women in the observation group in 24 h after operation were significantly lower than those (130.21±16.39 and 250.69±22.64) of the women in the control group (P<0.05), but there were no significant differences in the values of prothrombin time and thrombin time of the women between the two groups. Conclusion: Application of combined spinal and epidural anesthesia during cesarean section of the pregnant women with chronic hypertension complicating preeclampsia can achieve the stable of hemodynamics of the women with good anesthesia effectiveness.
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