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| Analgesic effect of preemptive analgesiaon by ketorolac tromethamine combined with sufentanil of the patients after hysterectomy |
| Suqian People's Hospital of Nanjing Gulou Hospital Group, Jiangsu Province, 223800 |
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Abstract To investigate the analgesic effect and safety of preemptive analgesiaon by ketorolac tromethamine combined with sufentanil of the patients after hysterectomy. Methods: 184 patients who wanted laparoscopic hysterectomy in selected time were randomly divided into experimental group (n=92) and control group (n=92) from January 2018 to January 2020. The patients in both groups were given preemptive analgesia at 30min before skin incision, and the patients in the control group were given 10μg sufentanil as preemptive analgesia, while the patients in the experimental group were given 5μg sufentanil combined with 15mg ketorolac tromethamine as preemptive analgesia. After operation, all patients were given controlled intravenously analgesia (PCIA), and the patients in the control group were given 1μg/kg sufentanil, while the patients in the experimental group were given 3mg/kg ketorolac tromethamine combined with 1μg/kg sufentanil. The visual analogue scale (VAS) scores of the patients in the two groups immediately after operation (T1), 2h after operation (T2), 6h after operation (T3), 12h after operation (T4), 24h after operation (T5), and 2h after PCIA withdrawal (T6) were observed. The levels of serum substance P and serotonin (5HT) of the patients in the two groups before anesthesia (T0), at T2 and T5 were detected. The incidences of postoperative analgesic adverse reactions of the patients in the two groups were recorded. Results: VAS scores at T1 (2.95±0.77 points), T2 (3.41±0.75 points), T3 (3.12±0.79 points) of the patients in the experimental group were significantly lower than those (3.33±0.69 points, 3.86±0.84 points, and 3.45±0.75 points) of the patients in the control group (P<0.05), but which of the patients at T4, T5 and T6 had no significant different between the two groups (P>0.05). The levels of serum substance P and 5-HT of the patients in the experimental group at T2, T5, and T6 were significantly lower than those of the patients in the control group. The total incidence of adverse analgesia reaction (5.4%) of the patients in the experimental group was significantly lower than that (15.2%) of the patients in the control group (all P<0.05). Conclusion: Ketorolac tromethamine combined with sufentanil used as preemptive analgesia of the patients with hysterectomy can significantly reduce the level of their serum pain-causing substances during early postoperative stage, with good postoperative analgesic effect and low incidence of adverse reactions.
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