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| Impact of spontaneous abortion on the risk of subsequent preterm birth in women receiving free pre-pregnancy health examination in Yunnan province |
| 1.Yunnan Population and Family Planning Research Institute, Key Laboratory of Preconception Health in Western China, Kunming, Yunnan Province, 650021; 2. Key Laboratoryof National Health Commission for Family Planning and Contraceptives, Shanghai Institute for Biomedical and Pharmaceutical Technologie |
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Abstract To explore the association of spontaneous abortion with the risk of subsequent preterm birth. Methods: The data of the objects in this study were from the archival information of couples who intended to have a child and had pre-pregnancy health examination under the National free pre-pregnancy health examination project in Yunnan province between 2010 and 2017. The pregnancy situation and pregnancy outcomes of the objects were followed up after examination. Describe analysis, stratified analysis, and logistic regression model were performed for data analysis by using SAS 9.4. Results：A total of 173,663 pregnancies were included in this analysis. Of them, 3.1% had a history of spontaneous abortion, 4.5% (95% CI 4.38-4.57) women had reported the preterm births for terminating the pregnancy. Results of multivariate logistic regression analysis indicated that the risk of subsequent preterm birth in women having one spontaneous abortion history (OR 0.94, 95%CI: 0.82-1.07), and those having two or more spontaneous abortions were largely similar (OR 1.02, 95%CI: 0.75-1.39) to that in women having no previous spontaneous history. Conclusion：A previous spontaneous abortion history does not increase the risk of subsequent preterm birth.
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