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Abstract To explore the value of fetal middle cerebral artery (MCA) and umbilical artery (UA) blood flow monitored by ultrasound combined with cerebroplacental ratio (CPR) for diagnosing the fetal growth restriction (FGR) of pregnant women with preeclampsia (PE). Methods: The clinical data of 96 pregnant women with PE from February 2020 to February 2022 were collected retrospectively. And these women were divided in group A (52 women with FGR) and group B (44 women without FGR) according to the occurrence of FGR. The values of flow parameters of the fetal MCA and UA, and the CPR were compared between two groups, and the diagnostic efficacy of which for PE complicating FGR was analyzed. Results: There was no significant difference in the age and the gestational weeks of the women between the two groups (P>0.05). The neonatal body weight of the women in group A was significantly lower than that of the women in group B (P＜0.05). The value of blood flow parameters of fetal MCA, such as systolic peak flow velocity/ end-diastolic peak flow velocity (S/D), resistance index (RI), and pulsatile index (PI), of the fetal MCA and UA in group A were significantly lower than those in group B. The values of S/D, RI, and PI of fetal UA in group A were significantly higher than those in group B. The CPR in group A was significantly lower than that in group B (all P＜0.05). The area under the curve (AUC) of the value of S/D, RI, or PI of the fetal MCA, the value of S/D, RI, or PI of the fetal UA, or CPR for diagnosing FGR of the pregnant women with PE was 0.773, 0.789, 0.789, 0.738, 0.746, 0.758, or 0.801, respectively. The diagnosis efficiency of the combined of the values of S/D, RI, and PI of the fetal MCA, the values of S/D, RI, and PI of the fetal UA, and CPR for diagnosing FGR of the women had increased, and the AUC, the specificity, and the sensitivity of which were 0.934, 88.6%, and 84.6%, respectively. Conclusion: The flow parameters values, such as S/D, RI, and PI, and CPR of the fetal MCA and UA have certain diagnostic efficacy for FGR of the pregnant women with PE, and the combined detections of which has the highest diagnostic efficacy.
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