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| Analysis of risk factors of macrosomia delivered by women with gestational diabetes mellitus |
| Haian People's Hospital, Nantong, Jiangsu Province, 226000 |
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Abstract To investigate the risk factors of macrosomia delivered by pregnant women with gestational diabetes mellitus (GDM). Methods: The clinical data of 318 pregnant women with GDM from September 2019 to March 2021 were analyzed retrospectively. These women were divided into group A (82 women with macrosomia)and group B (236 women with normal weight newborns). The levels of blood glucose, secreted frirzzled-relaled prolein 4 (sFRP4), and ficolin-3 of the women were compared between the two groups. Multivariate Logistic regression was used to analyze the risk factors of macrosomia. Results: The fasting blood glucose (FBG)level (5.04±0.36 mmol/L)of the women in group A during 28-32 gestational weeks was significantly higher than that (4.71±0.43 mmol/L)of the women in group B (P＜0.05). There was no significant difference in the 1h blood glucose (BG)level of the oral glucose tolerance test (OGTT)of the women between the two groups (P＞0.05). The levels of 2hBG and 3hBG (8.78±1.34 mmol/L and 7.41±1.12 mmol/L)of the women in group A were significantly higher than those (8.26±1.38 mmol/L and 6.98±1.11 mmol/L)of the women in group B (P＜0.05). The levels of sFRP4 and ficolin-3 (125.79±30.78 ng/ml and 26.98±5.12 ng/ml)of the women in group A were significantly higher than those (105.98±25.52 ng/ml and 23.33±3.30 ng/ml)of the women in group B (P＜0.05). Multivariate analysis showed that maternal age ≥26 years old, the sFRP4 level ≥95.5 ng/ml, the ficolin-3 level ≥21 ng/ml, the FPG level ≥4.7 mmol/L during 28-32 gestational weeks, the values of maternal pre-pregnancy body mass index ≥25 kg/m2, and the abnormal gestational weight gain of the women were the risk factors of macrosomia (P＜0.05). Conclusion: The blood glucose level of the pregnant women with GDM during28-32 gestational weeks is abnormal, and their sFRP4 and ficolin-3 levels increase abnormally. The maternal age, the sFRP4 level, the ficolin-3 level, the FPG level during 28-32 gestational weeks, the maternal pre-pregnancy body mass index, and the abnormal gestational weight gain of the women were the risk factors of their macrosomia.
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