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Abstract To analyze the differences of blood lipid and sex hormone levels of patients with polycystic ovary syndrome (PCOS) and different thyroid stimulating hormone (TSH) levels. Methods: 82 patients with PCOS were included in observation group, and 70 childbearing age women with the same age and regular menstruation were enrolled in control group. The percentage of the patients with TSH >4.0 μIU/ml was compared between the two groups. And the patients in the observation group were further divided group A (patients with TSH >4μIU/ml) and group B (patients with TSH ≤4μIU/ml) according to their TSH levels. The detection rates of obesity, abdominal obesity, insulin resistance (IR), hyperandrogenemia, and positivity of thyroid-related antibodies of the patients were compared between group A and group B. The endocrine metabolic parameters, such as fasting blood glucose (FBG), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), estradiol (E2), progesterone (P), total testosterone (T), prolactin (PRL), luteinizing hormone (LH), follicle stimulating hormone (FSH), and LH/FSH of the patients in the observation group were recorded. Results: The proportion of the patients with TSH >4.0μIU/ml (23.5%) in observation group was significantly higher than that (2.9%) the patients in the control group (P＜0.05). In the observation group, the detection rates of obesity, abdominal obesity, IR, and positivity of thyroidrelated antibodies of the patients in group A were significantly higher than those of the patients in group B. The levels of E2, P, T, and HDL-C of the patients in group A were significantly lower than those of the patients in group B. The levels of RPL, TG, FBG, and FINS, and the HOMA-IR value of the patients in group A were significantly higher than those of the patients in group B (all P＜0.05). Conclusion: The incidence of the elevated TSH level of the patients with PCOS is higher than that of the normal women, and the increase of TSH level aggravates the obesity and IR of the patients with PCOS. The increase of THS level may affect the reproductive and endocrine disorders of the patients with PCOS by affecting their sex hormones and glucose and lipid metabolism.
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