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| Value of Doppler ultrasound combined with the levels of serum human chorionic gonadotropin, progesterone, and estradiol for predicting the outcomes of threatened abortion |
| 1. West China Guang'an Hospital of Sichuan University, Guang'an, Sichuan Province,638000；2. The People's Hospital of Lincang City, Yunnan Province |
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Abstract To explore the value of Doppler ultrasound combined with the levels of serum human chorionic gonadotropin (β-hCG), progesterone (P), and estradiol (E2) of pregnant women for predicting their pregnant outcomes of threatened abortion after preventing miscarriage. Methods: The clinical data of 294 pregnant women with threatened abortion between January 2019 and December 2020 were collected, and all of these women were given fetal-preservation treatment for 4 weeks. According to the pregnancy outcomes of the women after treatment, these women were divided into group A (192 women with pregnancy continuity) and group B (102 women with pregnancy failure). The levels of serum β-hCG, P, and E2, and the values of uterine spiral artery blood flow signal parameters examined by Doppler ultrasound examination, such as pulsatility index (PI), resistance index (RI), ratio of peak systolic velocity to end diastolic velocity (S/D), of the women in both groups were analyzed. The diagnostic positive rates of the levels of serum β-hCG, P, and E2, and the values of PI, RI, and S/D of the women for their threatened abortion were compared between the two groups. The predictive value of the diagnostic positive rates of the levels of serum β-hCG, P, and E2, and the values of PI, RI, and S/D of the women for the pregnancy outcomes of the women with threatened abortion was analyzed by receiver operating characteristic (ROC) curve. Results: The serum levels of β-hCG, P, and E2 of the women in group B were significantly lower than those of the women in group A, and the values of PI, RI, and S/D of the women in group B were significantly higher than those of the women in group A. The positive coincidence rates of serum β-hCG, P, and E2, and the values of spiral artery blood flow signal parameters of the women in group B were significantly higher than those of the women in group A (all P＜0.05). ROC curve analysis showed that the area under the curve of the combination of the levels of β-hCG, P, and E2, and the values of RI, PI, and S/D for predicting the pregnancy outcomes of the women with threatened abortion was 0.963, which was significantly higher than that of the β-hCG level, the P level, the E2 level, the RI value, the PI value, or the S/D value alone (P＜0.05). The accuracy, the sensitivity, and the specificity of the combination of the levels of β-hCG, P, and E2, and the value of RI, PI, and S/D for predicting the pregnancy outcomes of the women with threatened abortion were 92.5%, 94.2%, and 94.8%, respectively, which all had increased significantly. Conclusion: The serum levels of β-hCG, P, and E2 of the women with pregnancy failure decrease, while the RI, PI and S/D values of uterine spiral artery of these women increase. The value of the combination of the levels of β-hCG, P, and E2, and the value of RI, PI, and S/D for predicting the pregnancy outcomes of the women with threatened abortion is better in clinic.
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