|
|
|
| Clinical effect of loop electrosurgical excision procedure combined with estrogen supplementary therapy for treating perimenopausal women with human papillomavirus positive and low-grade cervical intraepithelial neoplasia |
| 1.Longquanyi District Maternity and Child Health Care Hospital of Chengdu，Chengdu, Sichuan Province, 610100; 2. The Second Affiliated Hospital of Chengdu Medical College, Nuclear Industry 416 Hospital |
|
|
|
|
Abstract To study the effect of loop electrosurgical excision procedure (LEEP)combined with estrogen supplementary therapy for treating perimenopausal women with positive human papillomavirus (HPV)and low-grade cervical intraepithelial neoplasia (CIN), and to explore its influence on the sex hormone level of these women. Methods: A total of 144 perimenopausal women with persistent HPV infection and low-grade CIN were selected and were randomly divided into two groups (72 cases in each group)according to the random number table from January 2018 to January 2019. The women in the two groups were given LEEP treatment. The women in the observation group were also given oral estradiol valerate (2-3 mg/time, twice a day)for three months after surgery additionally. The perioperative indicators and complications situation of the women in the two groups were observed. The HPV nucleic acid quantification and the HPV negative conversion rate of the women in the two groups were recorded. Results: The postoperative vaginal bleeding time (5.1±0.8d), the vaginal discharge time (6.1±1.0d), and the section healing time (28.7±5.8d)of the women in the observation group were significantly lower than those (7.6±0.9d, 8.3±1.1d, and 36.4±6.9d)of the women in the control group (all P＜0.05). There was no significant difference in the HPV negative rate (81.9% vs. 79.2%)of the women after surgery between the two groups (P＞0.05). The levels of LH and FSH of the women in the observation group were significantly lower than those of the women in the control group, the levels of E2 and P of the women in the observation group were significantly higher. The incidence of postoperative complications (7.0%)of the women in the observation group was significantly lower than that (18.1%)of the women in the control group (all P＜0.05). Conclusion: LEEP conization combined with estrogen supplementary therapy for treating perimenopausal women with HPV infection and low-grade CIN can effectively promote their postoperative recovery, reduce the occurrence of their postoperative complications, regulate the level of their sex hormones, and which help to treat the HPV infection and low-grade CIN of the women.
|
|
|
|
|
|
|
|
|
