To analyze the effects of combined spinal epidural anesthesia(CSEA)of women on their anesthesia effect, hemodynamics, and neonatal Apgar score. Methods: A total of 145 pregnant women with singleton pregnancy who met the guidelines of cesarean section were selected and were divided into 74 cases in group A(women with CSEA)and 71 cases in group B(women with EA)according to different anesthesia methods from January 2019 to January 2020. The effect of anesthesia, the hemodynamic indexes values, the neonatal Apgar scores, and the adverse reactions rate of the women were compared between the two groups. Results: The proportion of grade III anesthesia effect(93.2%)of the women in group A was significantly higher than that(33.8%)of the women in group B(P＜0.05). The MAP value of the women in group A after stable anesthesia or at the end of operation was significantly higher than that of the women in group B. The HR value of the women in group A at 10min after fetal delivery or at the end of operation was significantly higher than that of the women in group B(all P＜0.05). There was no significant difference in the SpO2 value of the women at different anesthesia moments between the two groups(P＞0.05). The neonatal Apgar score(9.11±0.25 points)at 1min after birth in group A was significantly higher than that(8.28±0.85 points)in group B(P＜0.05). There was no significant difference in the neonatal Apgar score(9.61±0.11 points vs. 9.59±0.21 points)at 5min after birth between the two groups(P＞0.05). There was no significant difference in the incidence of adverse reactions(10.8% vs.7.0%)of the women between the two groups(P＞0.05).  Conclusion: CSEA can maintain maternal hemodynamic stability to a certain extent, and which has no obvious adverse significant effect on the neonatal Apgar score, with good anesthesia effects and safety. It can be considered as one of the preferred anesthesia methods for cesarean section.