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| Correlation between YAP1 and TAZ expression in placenta tissues of women with severe preeclampsia and their perinatal outcome |
| Tthe First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan Province, 47100 |
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Abstract To investigate the correlation between YAP1 and TAZ expression in placenta tissues of pregnant women with severe preeclampsia(PE)and their perinatal outcomes. Methods: 220 pregnant women with PE were selected as the research objects from March 2018 to September 2020, which included 102 cases with mild preeclampsia in group A and 118 cases with severe preeclampsia in group B. And 72 healthy pregnant women were selected in group C during the same period. The mRNA and protein levels of YAP1 and TAZ in placenta tissue were measured by RT-PCR and immunohistochemistry. The mRNA and protein levels of YAP1 and TAZ of the women were compared among the three groups. Pearson correlation analysis was used to explore the correlation between the mRNA and protein expression levels of YAP1, TAZ of the women and the severity of their PE and their maternal pregnancy outcomes. Results: The mRNA and protein expressions of YAP1 and TAZ of the women in groups C, group A, and group B had decreased gradually(all P＜0.05). The positive rates of YAP1 and TAZ of the women in group C, group A, and group B had decreased gradually(all P＜0.05). The severity of PE of the women was negatively correlated with their mRNA and protein levels of YAP1 and TAZ(all P＜0.05). The placental weight of the women, and the neonatal birth weight and 1 minute Apgar score in groups C, group A, and group B had decreased gradually, and the mRNA and protein levels of YAP1 and TAZ of the women were positively correlated with their placental weight and their neonatal birth weight and 1 minute Apgar score(all P＜0.05). Conclusion: The expressions of YAP1 and TAZ in placenta tissue of the women with severe PE decrease, which are correlated with the adverse perinatal outcomes of these women.
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